- Prophylaxis of macrocytic anemias associated with vitamin B12 deficiency:
- IM 1g every 2-3 months
- IM 1g every 2-3 months
- Pernicious anemia and other macrocytic anaemias without neurological involvement:
- IM initially 1mg 3 times a week for 2 weeks, then 1mg every 2-3 months
- IM initially 1mg 3 times a week for 2 weeks, then 1mg every 2-3 months
- Pernicious anemia and other macrocytic anaemias with neurological involvement
- IM Initially 1mg OD on alternate days until no further improvement, then 1mg every 2 months
- IM Initially 1mg OD on alternate days until no further improvement, then 1mg every 2 months
- Tobacco amblyopia:
- IM initially 1mg OD *2/52, then 1mg twice weekly until no further improvement, then 1mg every 1-3 months
- IM initially 1mg OD *2/52, then 1mg twice weekly until no further improvement, then 1mg every 1-3 months
- Leber’s optic atrophy:
- IM initially 1mg OD *2/52, then 1mg twice weekly until no further improvement, then 1mg every 1-3 months
Injection: 1mg/mL
None remarkable
Hydroxocobalamin is a precursor of methylcobalamin and adenosylcobalamin, the active forms of vitamin B12.
Methylcobalamin is a cofactor for the enzyme methionine synthase, an essential enzyme in the formation of methionine from homocysteine which is essential the synthesis of purines and pyrimidines needed for DNA synthesis and red blood cell formation
- Diarrhoea
- Dizziness
- Headache
- Hot flush
- Nausea
- Skin reactions
- Urine discolouration
- Arrhythmia
- Chills
- Drug fever
- Hypokalaemia
- Malaise
- Pain
- Thrombocytosis
- Tremor
- Vomiting
None remarkable
None remarkable
Drug Status
| Availability | Prescription only |
| Pregnancy | Safe to use |
| Breastfeeding | Safe to use |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Cobalin-H | 1000mcg/mL | Injection | 5’s | Amdipharm | Surgipharm Ltd |