• Treatment of diabetes insipidus:
    • Adults:
      • Initially PO 0.05mg BD. Effective range: 0.1-1.2mg divided BD/TDS
      • Nasal: 0.2mL daily in two divided doses
    • 3 months-4 years:
      • Initially PO 0.05mg OD. Effective range: 0.1-0.8mg/day divided BD
    • >4 years:
      • Initially PO 0.05mg BD. Effective range: 0.1-1.2mg/day divided BD/TDS
      • Max: 1.2mg/day
    • 3 months-12 years:
      • Nasal: 0.05 to 0.3 mL daily, either as a single dose or divided into two doses.
  • Nocturnal enuresis:
    • Adults and >6 years:
      • PO 0.2mg every night at bedtime.
      • Max: 0.6mg/day
      • Restrict fluid intake >1h before administration until next morning or >8h after admin
  • Renal concentration capacity test:
    • Adults and >6 years:
      • PO 0.6mg x1
      • Give after bladder is emptied
  • Hemophilia A:
    • IV 0.3mcg/kg/dose x1 given over 15-30 minutes (for pre-op, 30 min before procedure)
  • Von Willebrand Disease (Type 1):
    • IV 0.3mcg/kg/dose x1 given over 15-30 minutes (for pre-op, 30 min before procedure)

Tablet:

  • 0.1mg
  • 0.2mg

Injection:

  • 4mcg/mL

Nasal spray:

  • 0.1mg/mL
  • Avoid caffeine and alcohol at bedtime

It increases water permeability in renal tubular cells, which in turn decreases urine volume and increases urine osmolality

  • Flushing
  • Headache
  • Rhinitis
  • Nausea
  • Abdominal pain
  • Dizziness
  • Cough
  • Epistaxis
  • Rigors
  • Conjunctivitis
  • Hypertension
  • Hypotension
  • Hypersensitivity to class/components
  • Patients <3 months (Hemophilia/ Von Willebrand disease)
  • CrCl <50
  • Von Willebrand disease Type IIb
  • Hyponatremia or history
  • Intranasal mometasone

                          Drug Status

Availability Prescription only
Pregnancy Category B; Can be used
Breastfeeding Can be used
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
DDVAP 0.2mg Tablet 100’s Ferring GMBH Macnaughton Ltd
DDVAP 0.1mg Tablet 90’s Ferring GMBH Macnaughton Ltd
DDVAP 4mcg/mL Injection 10’s Ferring GMBH Macnaughton Ltd
DDVAP 0.1mg/mL Nasal spray 5mL Ferring GMBH Macnaughton Ltd