- Moderate-severe atopic dermatitis:
- Adults and ≥15 years:
- 0.03% or 0.1% ointment: Apply thin layer to affected area BD
- 0.03% or 0.1% ointment: Apply thin layer to affected area BD
- Adults and ≥15 years:
-
- 2-15 years:
- 0.03% ointment: Apply thin layer to affected area BD
- 2-15 years:
Ointment: 0.1% w/w; 0.03%w/w
- Do not use with occlusive dressings
- Reevaluate if symptoms persist >6 weeks
Calcineurin inhibitor; Immunosuppressant
The exact mechanism is unknown but it is thought to inhibit T-cell activation by binding to intracellular proteins and complexes with calcineurin dependent proteins
- Skin burning
- Pruritus
- Influenza-like symptoms
- Erythema
- Headache
- Skin infection
- Hypersensitivity reaction
- Fever
- Infection
- Asthma
- URI
- Cough
- Rash
- Urticaria
- Otitis media
- Folliculitis
- Acne
- Alcohol intolerance
- HSV infection
- VZV infection
- Photosensitivity
- Lymphadenopathy
- Hypersensitivity to class/components
- Breastfeeding if applied on nipples
- Patients <2 years
- Immunocompromised patients
- Pre-malignant and malignant skin condition
- Treatment site infection
- Skin barrier defect condition
- Netherton syndrome
- Lamellar ichthyosis
- Generalized erythroderma
- Cutaneous GVHD
WARNING
- Rare skin malignancies and lymphoma reported following topical calcineurin inhibitor use
- Avoid long-term use and limit application to areas of atopic dermatitis
- Not indicated for use in children <2 years
- Only 0.03% ointment indicated for children aged 2-15 years
None remarkable
Drug Status
| Availability | Prescription only |
| Pregnancy | Can be used |
| Breastfeeding | Avoid application to nipple area otherwise can be used |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Immugraft | 0.03% w/w | Ointment | 10g | Rainbow Life Sciences | Europa Healthcare |
| Remus Adult | 0.1% w/w | Ointment | 10g | Square Pharma | Ace Pharma |
| Remus Paeds | 0.03% w/w | Ointment | 10g | Square Pharma | Ace Pharma |
| Rocimus | 0.03% w/w | Ointment | 10g | Mega Lifesciences | Mega Lifesciences |
| Rocimus | 0.1% w/w | Ointment | 10g | Mega Lifesciences | Mega Lifesciences |
| Tacrovate Forte | 0.1% w/w | Ointment | 20g | Ochoa Labs | Medisel Kenya |
| Tacroz | 0.03% w/w | Ointment | 10g | Glenmark Pharma | Glenmark Pharma |
| Tacroz Forte | 0.1% w/w | Ointment | 10g | Glenmark Pharma | Glenmark Pharma |
| Talimus | 0.1% w/w | Ointment | 10g | Ajanta Pharma | Harley’s Ltd |
| Talimus | 0.03% w/w | Ointment | 10g | Ajanta Pharma | Harley’s Ltd |