• Corticosteroid-responsive conditions:
    • IM 60mg *1
    • Range: 40-80mg *1
  • Allergic conditions:
    • IM 40-100mg *1
  • Acute exacerbation of multiple sclerosis:
    • IM 160mg OD *1/52, then IM 64mg OD *1/12
  • Acute gout:
    • Small joints: 5-5mg intra-articularly *1
      • Max: 10mg/site up to 80mg/total dose
  • Large joints: 5-15mg intra-articularly *1
    • Max: 40mg/site up to 80mg/total dose
  • Rheumatoid arthritis or osteoarthritis:
    • Small joints: 5-5mg intra-articularly *1
      • Max: 10mg/site up to 80mg/total dose
    • Large joints: 5-15mg intra-articularly *1
      • Max: 40mg/site up to 80mg/total dose
  • Steroid-responsive dermatoses:
    • Intralesional injection: 1mg per injection site 1 or more times weekly
      • Max 30mg/day
  • Joint and joint structure inflammation:
    • Small joints: 5-5mg intra-articularly *1
      • Max: 10mg/site up to 80mg/total dose
    • Large joints: 5-15mg intra-articularly *1
      • Max: 40mg/site up to 80mg/total dose

Injection: 40mg

  • With intra-articular administration, use a local anesthetic prior
  • When administered intralesionally, inject directly into the lesion

Corticosteroid

It inhibits multiple inflammatory cytokines, producing multiple glucocorticoid and mineralocorticoid effects

  • Joint swelling
  • Post-injection flare (intra-articular use)
  • Cushingoid appearance
  • Hirsutism
  • Weight gain
  • Erythema
  • Abdominal discomfort
  • Appetite changes
  • Emotional lability
  • Rash
  • Urticaria
  • Nausea
  • Vomiting
  • Sodium retention
  • Fluid retention
  • Hypokalemia
  • Elevated BP
  • Edema
  • Diaphoresis
  • Muscle atrophy
  • Impaired wound healing (long-term use)
  • Skin atrophy (long-term use)
  • Petechiae
  • Ecchymosis
  • Skin pigmentation abnormality
  • Acne
  • Headache
  • Dizziness
  • Vertigo
  • Insomnia
  • Depression
  • Anxiety
  • Glucose intolerance
  • Cushing syndrome (long-term use)
  • Menstrual irregularities
  • Increased IOP
  • Hypersensitivity to class/components
  • IV use
  • Intrathecal, intraocular or intradermal use
  • Epidural use
  • Neonates
  • Premature infants
  • Thrombocytopenic purpura (IM use)
  • Systemic fungal infection
  • Cerebral malaria
  • Latent or active amebiasis
  • Unstable joint (intra-articular use)
  • Joint infection or history (intra-articular use)
  • Traumatic brain injury (high-dose use)
  • Abrupt withdrawal (high-dose or long-term use)
  • Live bacterial vaccines
  • Desmopressin
  • Mifepristone
  • Tamoligene

                          Drug Status

Availability Prescription only
Pregnancy Category C
Breastfeeding Weigh risk vs benefit
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Cenolon 40mg Injection 1’s Radiance Pharma Radiance Pharma
Kenalog 40mg Injection 5’s Bristol-Myers Squibb Bristol-Myers Squibb
Triam-Denk 40mg Injection 10’s Denk Pharma Laborex Kenya
Trinocort 40mg Injection 1’s Asence Pharma Medisel Kenya