• Muscle spasticity associated with multiple sclerosis and spinal cord injury:
    • Initially PO 2mg TDS/QID PRN
      • No more than 3 doses/ 24 hours
      • May increase by 2-4mg/dose every 1-4 days
  • Tablet:
    • 2mg
    • 4mg
  • Taper dose by 2-4mg/day to discontinue if prolonged, high-dose use
  • Give consistently with food or on empty stomach

Alpha-2 adrenergic receptor agonist

It binds to central alpha-2 adrenergic receptors, increasing presynpatic motor neuron inhibition and reducing spasticity (centrally-acting muscle relaxant)

  • Xerostomia
  • Somnolence
  • Asthenia
  • Dizziness
  • Hypotension
  • Orthostatic hypotension
  • Bradycardia
  • UTI
  • Infection
  • Constipation
  • Elevated ALT /AST
  • Vomiting
  • Speech disturbance
  • Urinary frequency
  • Blurred vision
  • Flu syndrome
  • Dyskinesia
  • Nervousness
  • Pharyngitis
  • Rhinitis
  • Hallucinations
  • Abrupt withdrawal (prolonged high-dose use)
  • Ciprofloxacin
  • Fluvoxamine
  • Viloxazine

                          Drug Status

Availability Prescription only
Pregnancy Category C
Breastfeeding Use alternative
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Relezin 2mg Tablet 30’s The United Pharma The United Pharma
Relezin 4mg Tablet 30’s The United Pharma The United Pharma
Tizigesic 2mg Tablet 30’s Unichem Labs Europa Healthcare
Tizigesic 4mg Tablet 30’s Unichem Labs Europa Healthcare