- Endotracheal intubation, mechanical ventilation:
- Adult: IV 0.4-0.5mg/kg over 60 seconds, then 0.08-0.1mg/kg 20-45 minutes after initial dose to maintain neuromuscular block
- Repeat maintenance dose every 15-25min PRN
- Decrease dose to IV 0.25-0.35mg/kg/dose x1 if under isoflurane or enflurane anesthesia, 0.3-0.4mg/kg/dose IV x1 if following succinylcholine-assisted intubation, in severe CV disease or anaphylactic reaction history OR
- Adult: IV 0.4-0.5mg/kg over 60 seconds, then 0.08-0.1mg/kg 20-45 minutes after initial dose to maintain neuromuscular block
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- Continuous IV infusion: 0.005-0.01mg/kg/min (ranges from 0.002-0.015mg/kg/min)
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- 1 month-2 years: IV 0.3-0.4mg/kg under halothane anesthesia
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- >2 years: IV 0.4-0.5mg/kg over 60 seconds, then 0.08-0.1mg/kg 20-45 minutes after initial dose to maintain neuromuscular block
- Maintenance dose every 15-25min PRN
- IV 0.3-0.4mcg/kg/dose IV if following succinylcholine-assisted intubation, severe CV disease or history of anaphylactic reaction
- >2 years: IV 0.4-0.5mg/kg over 60 seconds, then 0.08-0.1mg/kg 20-45 minutes after initial dose to maintain neuromuscular block
Injection: 10mg/mL
- Not for IM injection due to tissue irritation
- May be given undiluted as bolus injection
- Administration via infusion requires use of an infusion pump
- Use infusion solutions within 24 hours of preparation
- To be refrigerated
It is a non-depolarizing skeletal muscle relaxant; cholinergic receptor antagonist
- Skin flushing
- BP changes
- Elevated HR
- Hypersensitivity to class/compound
- IM use
- < 1 month old
- Lack of ventilator support
- Neuromuscular disease
- Amikacin
- Gentamicin
- Neomycin
- Paromomycin (aminosidine)
- Plazomicin
- Polymyxin B
- Quinidine (anti-arrhythmic)
- Streptomycin
- Tobramycin
Drug Status
| Availability | Prescription only |
| Pregnancy | Use when benefit outweighs risk |
| Breastfeeding | Use with caution |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Artacil 25mg | 25mg/2.5mL | Injection | 5’s | Neon Labs | Ripple Pharma |
| Atracurium | 50mg/5mL | Injection | 1’s | Galaxy Pharma | Galaxy Pharma |
| Atracurium-Hameln | 50mg/5mL | Injection | 10’s | Hameln Pharma | Hameln Pharma |
| Atrapure | 25mg/2.5mL | Injection | 5’s | Samarth Life Sciences | Nairobi Enterprises |
| Tracrium | 50mg/5mL | Injection | 5’s | Beta Healthcare | Beta Healthcare |