• Maintenance treatment in asthma/COPD:
    • PO 300-400mg OD *3/7, then 400-600mg OD
    • Max: 400mg/day if reduced clearance
  • Adjunct treatment in acute bronchospasm:
    • Loading:
      • Patients not currently taking theophylline: PO 5-7mg/kg
      • Aminophylline: IV 6-7mg/kg infused over 20 minutes
    • Maintenance: PO 4.8-7.2mg/kg BD
  • Neonatal apnea:
    • Loading: PO 4-5mg/kg
    • Maintenance: PO 3-6mg/kg/day divided TDS
  • Tablet:
    •  250mg
    • 400mg
    • 600mg

None remarkable

Xanthine derivative

It relaxes smooth muscles of respiratory tract and suppresses the response of the airways to stimuli. It may increase tissue concentration of cyclic adenine monophosphate (cAMP), which induces release of epinephrine from the adrenal medulla cells

  • Nausea
  • Vomiting
  • Headache
  • Insomnia
  • Diarrhea
  • Irritability
  • Restlessness
  • Tremor
  • Transient diuresis
  • Hypersensitivity to class/components
  • Dipyridamole
  • Febuxostat
  • Riociguat
  • Viloxazine

                          Drug Status

Availability Prescription only
Pregnancy Category C
Breastfeeding Contraindicated
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Nuelin SA 250mg Tablet 56’s iNova Pharma Phillips Therapeutics
Unicontin 400mg Tablet 100’s Modi Mundipharma Europa Healthcare
Unicontin 600mg Tablet 100’s Modi Mundipharma Europa Healthcare