Fluticasone/ Salmeterol

Inhalation powder:

• 50mcg/25mcg
• 125mcg/25mcg
• 250mcg/25mcg
• 100mcg/50mcg
• 250mcg/50mcg
• 500mcg/50mcg

• Actuate before use by pumping 2 puffs in the air before use.
• Shake for 5 seconds before each use.
• Prime inhaler again if not used for >7 days
• Rinse mouth with water after use.

Salmeterol: Selective long-acting beta agonist (LABA); It works by selectively stimulating beta-2 adrenergic receptors, relaxing airway smooth muscle by stimulating intracellular adenyl cyclase resulting in increased cAMP levels

Fluticasone: Long acting inhaled trifluorinated corticosteroid; It inhibits multiple inflammatory cytokines

• URI
• Headache
• Pharyngitis
• Cough
• Sinusitis
• Nausea
• Vomiting
• Dyspepsia
• Bronchitis
• Pneumonia (COPD use)
• Hoarseness
• Dysphonia
• Throat irritation
• Dizziness
• Palpitations
• Tremor
• Taste changes
• Diarrhea
• Dermatitis
• Oral & esophageal candidiasis
• Central serous chorioretinopathy

• Hypersensitivity to class/components
• Severe hypersensitivity to milk protein (dry powder form)
• Status asthmaticus
• Acute asthma
• Acute bronchospasm
• Abrupt withdrawal
• Acute deteriorating COPD

• Darunavir
• Fosamprenavir
• Indinavir
• Lefamulin
• Lopinavir
• Nelfinavir
• Ritonavir
• Desmopressin
• Isocarboxazid
• Tranylcypromine