• Short-term treatment in weight management:
    • PO 15-30mg OD in the morning
  • Capsule:
    • 15mg
    • 30mg
  • Taken 1-2 hours before breakfast
  • Dose may be divided BD
  • Discontinue when tolerance occurs
  • Taper dose to discontinue in prolonged use

Anorectic

Exact mechanism of action unknown but is thought to act as a sympathomimetic agent, which may suppress appetite as well as increase metabolism.

  • Palpitations
  • Tachycardia
  • Elevated BP
  • Restlessness
  • Dizziness
  • Insomnia
  • Euphoria
  • Dysphoria
  • Tremor
  • Headache
  • Xerostomia
  • Unpleasant taste
  • Diarrhea
  • Constipation
  • Urticaria
  • Impotence
  • Libido changes
  • Hypersensitivity to drug or ingredient
  • MAO inhibitor use within 14 days
  • Pregnancy
  • Breastfeeding
  • Cardiovascular disease or history
  • Advanced arteriosclerosis
  • CrCl <15
  • Dialysis
  • Uncontrolled HTN
  • Hyperthyroidism
  • Glaucoma
  • Agitation
  • History of drug abuse
  • Abrupt withdrawal (prolonged high-dose use)
  • Isocarboxazid
  • Linezolid
  • Phenelzine
  • Procarbazine
  • Selegiline transdermal
  • Tranylcypromine
  • Yohimbe

                                   Drug Status

Availability Prescription only
Pregnancy Contraindicated
Breastfeeding Contraindicated
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Duromine 15mg Capsule 30’s iNova Pharma Phillips Therapeutics
Duromine 30mg Capsule 30’s iNova Pharma Phillips Therapeutics