• Severe recalcitrant nodular acne unresponsive to conventional therapy, including systemic antibiotics:
    • PO 0.5-1mg/kg/day divided BD *15-20 weeks
  • Capsule:
    • 10mg
    • 20mg
  • Swallow with a full glass of water to reduce esophageal irritation

Retinoid

It inhibits sebaceous gland function and keratinization reducing sebum formation

  • Nail disorder
  • Skin disorder
  • Pruritus
  • Dry mucous membranes
  • Epistaxis
  • Anemia
  • Back pain
  • Arthralgia
  • Myalgia
  • Hypertriglyceridemia
  • Conjunctivitis
  • Increased LFTs
  • Increased glucose
  • Headache
  • Neutropenia
  • Photosensitivity
  • Tinnitus
  • Edema
  • Fatigue
  • Malaise
  • Lymphadenopathy
  • Weight loss
  • Tachycardia
  • Palpitations
  • Gingival bleeding
  • Nausea
  • Arthritis
  • Tendinitis
  • Dizziness
  • Insomnia
  • Nervousness
  • Paresthesia
  • Weakness
  • Hyperuricemia
  • Abnormal menses
  • Hypersensitivity to isotretinoin or vitamin A
  • Pregnancy
  • Breastfeeding during treatment and for at least 8 days after discontinuation

WARNING

NOT to be used in female patients who are or may become pregnant, because therapy poses an extremely high risk for severe birth effects (with any dose or duration)

None restricted

                          Drug Status

Availability Prescription only
Pregnancy Category X
Breastfeeding Contraindicated
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
D’Acne 10mg Tablet 30’s Glenmark Pharma Glenmark Pharma
D’Acne 20mg Tablet 30’s Glenmark Pharma Glenmark Pharma
Isotrin 10mg Capsule 30’s Surgilinks Ltd C/O Stallion Labs Surgilinks Ltd
Isotrin 20mg Capsule 30’s Surgilinks Ltd C/O Stallion Labs Surgilinks Ltd
Roaccutane 10mg Capsule 30’s F. Hoffman-La Roche Roche Kenya
Roaccutane 20mg Capsule 30’s F. Hoffman-La Roche Roche Kenya