- Amenorrhoea, dysfunctional uterine bleeding:
- PO/Vaginal 400mg OD *10/7
- IM 5-10mg *6-8 days
- PO/Vaginal 400mg OD *10/7
- Prevention of endometrial hyperplasia:
- PO/Vaginal 200mg nocte *12/7 every 4 weeks
- PO/Vaginal 200mg nocte *12/7 every 4 weeks
- Recurrent miscarriage with progesterone deficiency:
- PO/Vaginal 25-100mg twice per week from 15th day of pregnancy until 8-16 weeks.
- PO/Vaginal 25-100mg twice per week from 15th day of pregnancy until 8-16 weeks.
- Support of luteal phase:
- 1 applicator-full of vaginal gel OD/BD
- May continue for *10-12 weeks if pregnancy occurs
- Tablet/Pessary/Suppository:
- 100mg
- 200mg
- 400mg
- 600mg
- Vaginal gel:
- 8% w/v
To be taken without regard to food.
It inhibits pituitary gonadotropin release, blocking follicular maturation and ovulation. It also transforms proliferative into secretory endometrium. Maintains pregnancy.
- Headache
- Breast tenderness
- Dizziness
- Abdominal pain
- Depression
- Viral infections
- GI discomfort
- Acne
- Dysmenorrhea
- Irritability
- Vaginal discharge
- Hypersensitivity to progesterone products
- History of thromboembolic disorders
- History or current diagnosis of breast cancer
- Progesterone-dependent carcinoma
- Pregnancy
- Missed abortion or ectopic pregnancy
- Undiagnosed vaginal bleeding
- Cerebral apoplexy
WARNING
- Estrogen and progestin treatment may increase risk of invasive breast cancer in postmenopausal women
- Increased risk of MI, stroke and PE/DVT in postmenopausal women of 50-79 years
- Tranexamic acid
Drug Status
| Availability | Prescription only |
| Pregnancy | Category B; Safe to use |
| Breastfeeding | Safe to use |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Crinone | 8% w/w | Vaginal Gel | 15’s | Merck Ltd | Merck Ltd |
| Gestaglen | 100mg | Capsule | 30’s | Glenmark Pharma | Glenmark Pharma |
| Gestaglen | 200mg | Capsule | 30’s | Glenmark Pharma | Glenmark Pharma |
| Prontogest | 200mg | Pessary | 30’s | Marcyrl Pharma | Marcyrl Pharma |
| Prontogest | 400mg | Pessary | 30’s | Marcyrl Pharma | Marcyrl Pharma |
| Prostar | 200mg | Capsule | 30’s | Unosource Pharma | Unisel Ltd |
| Prostar | 0.8% w/v | Pre-Filled Syringe | 1’s | Unosource Pharma | Unisel Ltd |
| Prostium | 200mg | Capsule | 20’s | Olive Healthcare | Highchem Marketing |
| Susten | 200mg | Tablet | 30’s | Sun Pharma | Sun Pharma |
| Susten | 400mg | Tablet | 30’s | Sun Pharma | Sun Pharma |
| Utrogestan | 100mg | Capsule | 30’s | Besins Healthcare | Surgipharm Ltd |
| Utrogestan | 200mg | Capsule | 15’s | Besins Healthcare | Surgipharm Ltd |
| Utrogestan | 100mg | Pessary | 30’s | Besins Healthcare | Surgipharm Ltd |
| Utrogestan | 200mg | Pessary | 15’s | Besins Healthcare | Surgipharm Ltd |