Norethisterone

Endometriosis:
- PO 5mg BD on the 5^th day of the cycle. Increase to 10mg BD in case spotting occurs. Resume to initial dosing once bleeding stops. Duration of treatment: 4-6 months

Dysfunctional uterine bleeding:
- PO 5mg TDS *10/7
- Prevention of recurrence: 5mg BD from 19^th-26^th day of cycle

Primary and secondary amenorrhea:
- Administer estrogen before (e.g. for 14 days). Then combine estrogen and norethisterone PO 5mg OD/TDS * 10/7
- Stop estrogen once endogenous estrogen production has been achieved and continue with norethisterone 5mg BD between 16^th-25^th days of cycle to induce cycle bleeding.

Premenstrual syndrome, cyclical mastopathy:
- PO 5mg BD/TDS from 19^th-26^th day of cycle

Timing of menstruation:
- PO 5mg BD/TDS beginning about 3 days before expected menstruation. Bleeding will occur 2 to 3 days after stopping medication.

Contraception:
- IM 200mg every 8 weeks for the first 3 injections then every 12 weeks
- Given on the first 5 days of the menstrual cycle.

Tablet: 5mg

Best taken at night to avoid stomach upset.

Testosterone-derivative progestin.

It inhibits the secretion of gonadotropins from pituitary gland, prevents follicular maturation & ovulation and stimulates growth of mammary tissues.

Drug Status

BRAND NAME	STRENGTH	FORMULATION	PACK SIZE	MANUFACTURER	DISTRIBUTOR
Dub-Sterone	5mg	Tablet	30’s	Dawa Ltd	Dawa Ltd
Ncnorm-P	5mg	Tablet	30’s	Unicure Remedies	Surgilinks Ltd
Norcolut	5mg	Tablet	100’s	Gedeon Richter	Globe Pharmacy
Noristerat	200mg/mL	Injection	1’s	Bayer Schering	Bayer Schering
Normens	5mg	Tablet	30’s	Renata Ltd	Harley’s Ltd
Noteron	5mg	Tablet	30’s	Radiance Pharma	Radiance Pharma
Prepost N	5mg	Tablet	30’s	Par Labs	Simba Pharma
Primolut Depot	250mg/mL	Injection	1’s	Bayer Schering	Bayer Schering
Primolut N	5mg	Tablet	30’s	Bayer Schering	Bayer Schering
Steron	5mg	Tablet	100’s	Ray Pharma	Ray Pharma