- Ovulation induction:
- SC 75 IU OD *14/7 for cycle 1
- May adjust dose by 37.5 units/day every week for subsequent cycles
- Max: 300 units/day
- Treatment maximum of 35 days, unless E2 rise indicates imminent follicular development
- Advice against sexual intercourse
- Spermatogenesis induction in male patients with hypogonadotropic hypogonadism:
- SC 150 IU 3 times/week
- Used in conjunction with hCG
- If azoospermia persists, may increase dose to 300 IU 3 times/week
- May need to administer for up to 18 months for adequate response
- Assisted reproductive technologies:
- Initially SC 150 IU OD starting cycle day 2 or 3, for up to 10 days until sufficient follicular development
- May adjust dose no more than 75-150 units/day every 3-5 days
- Max: 450 units/day
- For patients with suppressed endogenous gonadotropin levels, start 225 units OD
- Injection:
- 75 IU
- 300 IU
- 450 IU
- 900 IU
- Remove pen from refrigerator at least 30 min before injection to warm to room temperature
- Inject SC in abdomen
- Once opened or stored at room temperature, unused material discarded after 28 days
Recombinant follicle stimulating hormone (FSH)
It stimulates ovarian follicular growth in women and spermatogenesis in men
- Headache
- Ovarian cyst
- Nausea
- URI
- Intermenstrual bleeding
- Abdominal pain
- Gynecomastia (male patients)
- Seborrhea
- Fatigue
- Diarrhea
- Pelvic pain
- Ovarian hyperstimulation syndrome
- Flatulence
- Pain
- Decreased libido (male patients)
- Acne (male patients)
- Weight gain
- Vomiting
- Injection site reaction
- Hypersensitivity to components/class
- Primary gonadal failure
- Uncontrolled thyroid disease
- Uncontrolled adrenal dysfunction
- Uncontrolled pituitary dysfunction
- Breast cancer
- Ovarian cancer
- Uterine cancer
- Testicular cancer
- Hypothalamic tumor
- Pituitary tumor
- Organic intracranial lesion
- Abnormal uterine bleeding
- Non-PCOS-related ovarian cysts
None remarkable
Drug Status
| Availability | Prescription only |
| Pregnancy | Not indicated |
| Breastfeeding | Unknown |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Foligraf 75-MHP | 3.75 mg /vial | Injection | 1’s | Bharat Serum | Nairobi Enterprises |
| Folisurge | 75 IU/0.12mL | Pre-Filled Syringe | 1’s | Intas Pharma | Accord Healthcare |
| Folisurge | 1200 IU/1.92mL | Pre-Filled Syringe | 1’s | Intas Pharma | Accord Healthcare |
| Fostimon | 75 IU | Injection | 1’s | IBSA Institut Biochimique | IBSA Institut Biochimique |
| Fostimon | 150 IU | Injection | 1’s | IBSA Institut Biochimique | IBSA Institut Biochimique |
| Gonal-F | 75 IU | Pre-Filled Syringe | 1’s | Merck Ltd | Merck Ltd |
| Gonal-F Pen | 300 IU/0.5mL | Pre-Filled Syringe | 1’s | Merck Ltd | Merck Ltd |
| Gonal-F Pen | 450 IU/0.75mL | Pre-Filled Syringe | 1’s | Merck Ltd | Merck Ltd |
| Gonal-F Pen | 900 IU/1.5mL | Pre-Filled Syringe | 1’s | Merck Ltd | Merck Ltd |