- Contraception
- Moderate dysfunctional uterine bleeding (Off-label)
- Dysmenorrhea (Off-label)
- Endometriosis (Off-label)
Dose: 1 tab OD
To be started 1st Sunday after onset of menses
Tablet: 30mcg/150mcg
- Taken without regard to meals
- Restart >4 weeks postpartum or >6 weeks postpartum if breastfeeding
- Administered at the same time everyday
- Should start on day 1 of menstrual cycle or 1st Sunday after onset of menses
COCs
Ethinyl estradiol: It reduces release of LHRH from hypothalamus. It reduces release of gonadotropin from pituitary and increases synthesis of DNA, RNA and various proteins in target tissues
Levonorgestrel: Progestin. It inhibits secretion of gonadotropins from pituitary. It prevents follicular maturation and ovulation and stimulates growth of mammary tissues
- Bleeding irregularities
- Nausea & vomiting
- Breast tenderness
- Headache
- Abdominal distension
- Abdominal pain
- Edema
- Weight changes
- Emotional lability
- Depression
- Acne
- Chloasma
- Libido changes
- Elevated BP
- Glucose intolerance
- Increased cholesterol
- Contact lens intolerance
- Vulvovaginal candidiasis
- Hypersensitivity to class/components
- Pregnancy
- <4 weeks postpartum (non-breastfeeding patients)
- <6 weeks postpartum (breastfeeding patients)
- Estrogen or progestin-dependent cancer or history of the same
- Breast cancer or history
- Endometrial cancer
- Benign or malignant hepatic tumor
- Active hepatic disease
- Oral contraceptive-associated or pregnancy-associated cholestatic jaundice history
- Thrombophlebitis or history
- Thromboembolism or history
- Major surgery with prolonged immobilization
- Smokers >35 years
- Heavy smokers
- Thrombogenic valvular or rhythm heart disease
- CAD
- Cerebrovascular disease
- Acquired or hereditary thrombophilia
- Persistent SBP >160 or DBP >100
- Hypertension with vascular disease
- DM with vascular disease
- Migraine headache with/without aura patients >35 years
- Undiagnosed vaginal bleeding
- SLE
WARNING
Cigarette smoking increases risk of serious cardiovascular side effects from combined hormonal contraceptive use
- Cisapride
- Dasabuvir
- Fosamprenavir
- Ombitasvir
- Paritaprevir
- Ritonavir
- Thioridazine
- Tranexamic acid
Drug Status
Availability | Prescription or OTC by Pharmacist |
Pregnancy | Not recommended |
Breastfeeding | Not recommended |
Schedule | Not controlled |
BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
---|---|---|---|---|---|
Femiplan | 30mcg/150mcg | Tablet | 28’s | Mylan Labs | Surgilinks Ltd |
Lyna | 30mcg/150mcg | Tablet | 21’s | West-Coast Pharma | Ray Pharma |
Microgynon | 30mcg/150mcg | Tablet | 21’s | Bayer Schering | Bayer Schering |
Microgynon Fe | 30mcg/150mcg | Tablet | 28’s | Bayer Schering | Bayer Schering |
Microgynon FE | 30mcg/150mcg | Tablet | 28’s | Bayer Schering | Bayer Schering |
Normen-C | 30mcg/150mcg | Tablet | 21’s | Par Labs | Simba Pharma |