• Hormone replacement therapy:
    • Combine with estrogen therapy and take 10mg OD *14/7 
  • Dysmenorrhea:
    • 10mg BD from day 5 to 25 of your menstrual cycle. 
  • Endometriosis:
    • 10mg BD/TDS from day 5 to 25 of your menstrual cycle. 
  • Dysfunctional bleeding (to stop):
    •  10mg BD * 5-7 days 
  • Dysfunctional bleeding (to prevent bleeding):
    • 10mg BD from day 11 to 25 of the cycle 
  • Amenorrhea:
    • To be taken with an estrogen. Estrogen taken OD from day 1 to 25 of the cycle together with dydrogesterone BD from day 11 to 25 of cycle. 
  • PMS:
    • 10mg BD from day 11 to 25 of cycle. 
  • Irregular cycles:
    • 10mg BD from day 11 to 25 of cycle. 
  • Threatened abortion:
    • 40mg STAT then 10mg TDS until symptoms subside. 
  • Habitual abortion:
    • 10mg BD until 20th week of pregnancy.

Tablet: 10mg

  • The tablet should be swallowed with a full glass of water
  • Can be taken with or without food.
  • If the patient needs to take more than one tablet then proper time gap should be maintained between the two tablets.

Synthetic progesterone derivative.

It works by imitating the activities of the natural hormone progesterone.

  • Hypersensitivity reactions
  • Acne
  • Migraines
  • GI disturbances
  • Libido changes
  • Weight gain
  • Breakthrough bleeding
  • Breast changes
  • Mental depression
  • Fluid retention
  • Children <18 years.
  • Thrombo-embolic disorders
  • Undiagnosed vaginal bleeding
  • Galactose intolerance
  • Known or suspected progesterone neoplasm

                                   Drug Status

Availability Prescription or OTC by Pharmacist
Pregnancy Category D; Contraindicated unless needed in some cases
Breastfeeding Contraindicated
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Duphaston 10mg Tablet 20’s Abbott Labs Harley’s Ltd