• Contraception
  • Premenstrual dysphoric disorder
  • Moderate acne vulgaris
  • Moderate dysfunctional uterine bleeding (Off-label)
  • Dysmenorrhea (Off-label)
  • Endometriosis (Off-label)
  • Polycystic ovary syndrome (Off-label)

Dose: 1 tab OD

Tablet: 3mg/0.02mg

  • Restart >4 weeks postpartum or >6 weeks postpartum if breastfeeding
  • Administered at the same time everyday
  • Should start on day 1 of menstrual cycle or 1st Sunday after onset of menses

COCs

Ethinyl estradiol: Reduces LHRH release from hypothalamus and reduces gonadotropin release from pituitary

Drospirenone: Progestin; Spironolactone analogue with anti-mineralocorticoid and anti-androgenic activity

  • Increased cholesterol
  • Bleeding irregularities
  • Nausea & vomiting
  • Breast tenderness
  • Headache
  • Abdominal distension
  • Abdominal pain
  • Edema
  • Weight changes
  • Emotional lability
  • Depression
  • Acne
  • Chloasma
  • Fatigue
  • Irritability
  • Libido changes
  • Elevated BP
  • Glucose intolerance
  • Contact lens intolerance
  • Vulvovaginal candidiasis
  • Hypersensitivity to class/components
  • Pregnancy
  • <4 weeks postpartum (non-breastfeeding patientts)
  • <6 weeks postpartum (breastfeeding patients)
  • Estrogen or progestin-dependent cancer or history
  • Breast cancer or history
  • Benign or malignant hepatic tumor
  • Cholestatic jaundice history, oral contraceptive or pregnancy-associated
  • Hepatic disease or impairment
  • Renal impairment
  • Thrombophlebitis or history
  • Thromboembolism or history
  • Major surgery with prolonged immobilization
  • Smokers >35 years
  • Heavy smokers
  • Thrombogenic valvular or rhythm heart dz
  • CAD
  • Cerebrovascular disease
  • Acquired or hereditary thrombophilia
  • Persistent SBP >160 or DBP >100
  • Hypertension with vascular disease
  • DM with vascular disease
  • Adrenal insufficiency
  • Migraine headache with/without aura
  • Hyperkalemia
  • Undiagnosed vaginal bleeding
  • SLE

WARNING:

Cigarette smoking increases risk of serious cardiovascular side effects from combined hormonal contraceptive use

  • Atazanavir
  • Cisapride
  • Cobicistat
  • Dasabuvir
  • Ombitasvir
  • Paritaprevir
  • Ritonavir
  • Thioridazine
  • Tranexamic acid

                          Drug Status

Availability Prescription only
Pregnancy Contraindicated
Breastfeeding Avoid use if <6 weeks postpartum
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Delsia 3mg/0.03mg Tablet 21’s Sun Pharma Sun Pharma
Dronis 3mg/0.02mg Tablet 24’s Sun Pharma Sun Pharma
Yasmin 3mg/0.03mg Tablet 21’s Bayer Schering Bayer Schering