- Hyperthyroidism in adults:
- Mild: Initially PO 15mg/day divided TDS
- Moderate: Initially PO 30-40 mg/day divided TDS
- Severe: Initially PO 60mg/day divided TDS
- Maintenance: PO 5-30mg/day divided TDS
- Hyperthyroidism in children:
- Initially PO 0.5-0.7mg/kg/day OD/ or divided TDS
- Maintenance: PO 0.2mg/kg/day OD or divided TDS
- Max 30mg/day
- Grave’s disease:
- Adults: PO 10-20mg/day *1
- Children: PO 0.2-0.5mg/kg/day
- May subsequently taper or discontinue if TSH levels are normal
- Thyrotoxicosis (Off-label):
- Adults: PO 15-20mg every 4 hours during first day as adjunct to other agents
- Reduce frequency to OD /BD once patient is stable
- Reduce frequency to OD /BD once patient is stable
- Adults: PO 15-20mg every 4 hours during first day as adjunct to other agents
-
- Children: PO 0.5-1mg/kg/day divided TDS
Tablet: 5mg
None remarkable
Antithyroid agent
It is a prodrug of methimazole which works by inhibiting synthesis of thyroid hormone by blocking oxidation of iodine in thyroid gland thereby blocking synthesis of thyroxine (T4) and triiodothyronine (T3)
- Rash
- Urticaria
- Nausea
- Vomiting
- Dyspepsia
- Arthralgia
- Paresthesia
- Loss of taste
- Alopecia
- Myalgia
- Headache
- Pruritus
- Drowsiness
- Neuritis
- Edema
- Vertigo
- Hyperpigmentation
- Jaundice
- Sialadenopathy
- Lymphadenopathy
- Hypersensitivity to class/components
- Breastfeeding
- Pregnancy 1st trimester
- Eliglustat
- Sodium iodide I-131
Drug Status
Availability | Prescription only |
Pregnancy | Category D |
Breastfeeding | Contraindicated |
Schedule | Not controlled |
BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
---|---|---|---|---|---|
Anti thyrox | 5mg | Tablet | 100’s | Macleods Pharma | Sai Pharma |
Caral | 5mg | Tablet | 100’s | Metro Pharma | Metro Pharma |
Carbimazole | 5mg | Tablet | 100’s | Remedica Ltd | Twokay Chemicals |
Carbimex | 5mg | Tablet | 100’s | Pharma Life Science | Pharma Life Science |
En-Thyro | 5mg | Tablet | 100’s | Twokay Chemicals | Twokay Chemicals |
Neomercazole | 5mg | Tablet | 100’s | Amdipharm | Surgipharm Ltd |