- Chemotherapy-induced nausea & vomiting:
- IV 0.01mg/kg/dose *1 30 min before chemo OR
- PO 1mg 1 hour before chemotherapy, then 1mg 12 hours after 1st dose OR
- PO 2mg 1 hour before chemotherapy
- Radiation-induced nausea & vomiting:
- PO 2mg *1 1 hour before radiation therapy
- PO 2mg *1 1 hour before radiation therapy
- Post-operative nausea & vomiting:
- Prevention: 1mg IV push over 30 seconds
- Given before anesthetic induction or immediately before reversal of anesthesia
- Treatment: 1mg IV push over 30 seconds
- Max 3mg per day
- Prevention: 1mg IV push over 30 seconds
- Injection:
- 1mg
- 3mg
- Tablet:
- 1mg
Given diluted or undiluted
Selective 5-HT3 Antagonist; antiemetic
It selectively binds to 5-HT3 receptors both in the peripheral and central nervous system with primary effects in GI tract
- Injection site reaction (SC use)
- Headache
- Asthenia
- Constipation
- Diarrhea
- Fever
- Elevated LFTs
- Abdominal pain
- Dyspepsia
- Dizziness
- Hypersensitivity to class/components
- Neonates
- Premature infants
- Apomorphine
- Pimozide
- Thioridazine
- Dronedarone
Drug Status
| Availability | Prescription only |
| Pregnancy | Category B |
| Breastfeeding | Use with caution |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Grani-Denk | 1mg/mL | Suspension | 5’s | Denk Pharma | Laborex Kenya |
| Grani-Denk | 3mg/3mL | Suspension | 5’s | Denk Pharma | Laborex Kenya |
| Kytril | 1mg/mL | Injection | 5’s | F. Hoffman-La Roche | Surgipharm Ltd |
| Kytril | 3mg/3mL | Injection | 5’s | F. Hoffman-La Roche | Surgipharm Ltd |
| Kytril | 1mg | Tablet | 10’s | F. Hoffman-La Roche | Surgipharm Ltd |