- Acute nausea & vomiting following cytotoxic/radiotherapy:
- Children <35kg: 250 micrograms/kg TDS (max. 750 micrograms/kg per day)
- Adults and children >35kg: 10 mg TDS (max. 30mg/day)
- Gastro-intestinal pain in palliative care:
- Adult: 10 mg TDS before meals
- Functional dyspepsia:
- Adult: 10-20mg TDS before meals for a max. period of 12 weeks.
- NOT RECOMMENDED FOR CHILDREN
- Lactation (Off-label):
- 10mg TDS *5/7
Tablet:
- 10mg
Suspension:
- 1mg/mL
Suppository:
- 30mg
- 10mg
- Should be taken 15-30min before meals
Selective peripheral dopamine antagonist in the chemoreceptor trigger zone and stomach. It increases spontaneous gastric activity and antagonizes dopamine inhibition of gastric emptying. It also increases lower esophageal sphincter pressure and promotes esophageal and antral peristalsis.
Additionally, it has also been shown to increase frequency, amplitude, duration of duodenal contractions and reduce the small bowel transit time.
- Raised prolactin concentration (increased risk of galactorrhoea & gynecomastia)
- Decreased libido
- Breast tenderness
- Allergic reactions
- Headache
- Acute dystonic reactions
- Dry mouth
- Hypersensitivity reactions to the drug
- Neonates < 1 year.
- Patients > 60 years
- Intestinal obstruction
- Immediately after surgery
- Conditions where cardiac conduction is impaired
- Severe hepatic impairment
- Prolactinomas
- Bromocriptine
- Anti-muscarinic agents
- Opioid analgesics
Drug Status
| Availability | Prescription or OTC by Pharmacist |
| Pregnancy | Category B2; Contraindicated |
| Breastfeeding | Safe to use |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Deflux | 1mg/mL | Suspension | 100mL | Beximco Pharma | Madawa Pharma |
| Deflux | 10mg | Tablet | 100’s | Beximco Pharma | Madawa Pharma |
| Domi | 1mg/mL | Suspension | 30mL | Lincoln Pharma C/O Medox Pharma | Medox Pharma |
| Domi-10 | 10mg | Tablet | 100’s | Lincoln Pharma C/O Medox Pharma | Medox Pharma |
| Domperon | 10mg | Tablet | 100’s | Cadila Pharm | Cadila Pharm |
| Domperon | 1mg/mL | Suspension | 30mL | Cadila Pharm | Cadila Pharm |
| Domstal | 10mg | Tablet | 30’s | Torrent Pharma C/O Medox | Medox Pharma |
| Domstal | 1mg/mL | Suspension | 30mL | Torrent Pharma C/O Medox | Medox Pharma |
| Don-A | 10mg | Tablet | 100’s | The ACME Labs | Highridge Pharma |
| Lockit | 10mg | Tablet | 20’s | Universal Corporation | Universal Corporation |
| Lockit | 1mg/mL | Suspension | 30mL | Universal Corporation | Universal Corporation |
| Motilium | 1mg/mL | Suspension | 100mL | Janssen Pharma | Janssen Pharma |
| Motilium | 10mg | Tablet | 20’s | Janssen Pharma | Janssen Pharma |
| Motinorm | 10mg | Tablet | 100’s | Medley Pharma | Zawadi Healthcare |
| Motinorm | 1mg/mL | Suspension | 30mL | Medley Pharma | Zawadi Healthcare |
| Vomitin | 30mg | Suppository | 5’s | Bliss GVS | Prunus Pharma |
| Vomitin | 10mg | Suppository | 5’s | Bliss GVS | Prunus Pharma |