- Hypovolemia:
- Adult: IV 25g STAT
- Paeds: IV 0.5-1g/kg
- Max: 2 g/kg/day/dose
- May repeat dose x1 after 15-30min
- Hypoalbuminemia
- Adult: IV 50-75g *1
- Paeds: IV 0.5-1 g/kg/dose *1
- Burns:
- Start with IV 25g *1 24 hours after burn injury
- Adjust dose to maintain plasma protein concentration 2.5g/100mL or serum protein concentration 5.2g/100mL
- Max: 2 g/kg/day
- Acute Respiratory Distress Syndrome (ARDS):
- IV 25g over 30 minutes
- Repeat TDS, PRN up to 3 days
- Nephrotic syndrome:
- IV 25g OD * 7-10 days
- Use with diuretics
- Ovarian Hyperstimulation Syndrome:
- IV 50-100g infused over 4hrs
- Repeat every 4-12hrs PRN
- Paracentesis:
- IV 6-8g IV per 1000 mL ascitic fluid removed
- Max: 2 g/kg/day
- For ascites removal >4 L
- Neonatal hemolytic disease:
- IV 1 g/kg/dose x1
- Give 1 hour before exchange transfusion
Injection:
- 20g/100mL
- For IV use only
It increases intravascular oncotic pressure and causes fluid mobilization from interstitial into intravascular space
- Hypersensitivity reaction
- Dyspnea
- Hypotension
- Hypertension
- Tachycardia
- Bradycardia
- Nausea
- Vomiting
- Confusion
- Headache
- Hypersensitivity to components
- Severe anemia
- Heart failure
- Risk of volume overload
WARNING
- Do NOT use sterile water as diluent – risk of potential fatal hemolysis and acute renal failure
- None known
Drug Status
| Availability | Prescription only |
| Pregnancy | Safe to use |
| Breastfeeding | Unknown; Use with caution |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Albumin | 20% | Injection | 100ml | Synermed | Synermed |
| Alburel | 20% | Injection | 100mL | Galaxy Pharma | Galaxy Pharma |