• Short-term treatment of insomnia:
    • PO 5-10mg nocte

Tablet: 10mg

  • Given immediately before bedtime and >7 hours before planned awakening
  • Taken on an empty stomach
  • Reevaluate if insomnia persists after 7-10 days of treatment

Imidazopyridine sedative/hypnotic

It modulates omega-1 type GABA receptor via selective antagonism, resulting in increased chloride conductance, neuronal hyperpolarization, inhibition of action potential and a decrease in neuronal excitability that in turn produce sedative and hypnotic effects

  • Headache
  • Drowsiness
  • Dizziness
  • Lethargy
  • Drugged feeling
  • Back pain
  • Hypersensitivity reaction
  • Diarrhea
  • Sinusitis
  • Pharyngitis
  • Xerostomia
  • Lightheadedness
  • Influenza-like symptoms
  • Palpitations
  • Depression
  • Constipation
  • Rash
  • Hypersensitivity to class/components
  • Complex sleep behavior history
  • Alcohol use
  • Severe hepatic impairment

WARNING:

  • Complex sleep behaviors may occur including sleep-walking, sleep-driving and engaging in other activities while not fully awake
  • May result in serious injuries, including death
  • Discontinue immediately if patient experiences a complex sleep behavior
  • Calcium/magnesium/potassium/sodium oxybate
  • Sodium oxybate

                          Drug Status

Availability Prescription only
Pregnancy Category C
Breastfeeding Contraindicated
Schedule Controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Nitrest 10mg Tablet 30’s Sun Pharma Sun Pharma
Stilnox 10mg Tablet 14’s Sanofi-Aventis Ressourcethica Kenya
Zolpirex 10mg Tablet 20’s Centaur Pharma Sai Pharma