• Major depressive disorder:
    • PO 10mg OD
    • Dose should then be increased to 20mg/day, as tolerated
    • Consider decreasing dose to 5mg/day if higher doses are not tolerated
  • Tablet:
    • 5mg
    • 10mg
    • 20mg

To be taken without regards to meals

Serotonin Modulators antidepressants

The exact mechanism of action is unknown but it is thought to selectively inhibit serotonin reuptake, antagonize serotonin 5-HT3 receptors and agonize serotonin 5-HT1A receptors thereby increasing serotonergic activity in the CNS

  • Nausea
  • Diarrhea
  • Dizziness
  • Xerostomia
  • Constipation
  • Vomiting
  • Flatulence
  • Abnormal dreams
  • Pruritus
  • Sexual dysfunction
  • Hypersensitivity to components
  • MAO inhibitor use within 14 days
  • Abrupt withdrawal

WARNING

There is increased the risk of suicidal thoughts and behavior in pediatric and young adult patients

  • Isocarboxazid
  • Linezolid
  • Methylene blue
  • Phenelzine
  • Rasagiline
  • Selegiline
  • Tranylcypromine

                          Drug Status

Availability Prescription only
Pregnancy Category C; Weigh risk vs benefit
Breastfeeding Weigh risk vs benefit
Schedule Controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Brintellix 10mg Tablet 28’s H. Lundbeck A/S Phillips Therapeutics
Brintellix 20mg Tablet 28’s H. Lundbeck A/S Phillips Therapeutics