• Partial seizures:
    • Adjunct treatment:
      • Adult: PO 300mg BD increased by up to 600mg/day weekly. Max: 2400mg/day
      • 2-4 years: Initially PO 8-10mg/kg/day divided BD. Max 600mg/day
        • <20 kg: May consider starting with 16-20mg/kg/day. May titrate to higher dose over 2-4 weeks. Max 60mg/kg/day
      • 4-6 years: Initially PO 8-10mg/kg/day divided BD. Max 600mg/day
        • 20-29kg: PO 450mg BD
        • 1-39kg: PO 600mg BD
        • >39 kg: PO 900mg BD
    • Converting to monotherapy:
      • Adult: PO 300mg BD, increased by up to 600mg/day weekly. Max: 2400mg/day
      • Reduce and withdraw concomitant antiepileptic drugs (AEDs) over 3-6 weeks while reaching maximum oxcarbazepine dose in 2-4 weeks
      • 4-16 years: Initially PO 8-10mg/kg/day divided BD, while simultaneously reducing concomitant AEDs dose(s) over 3-6 weeks
        • 20-24.99kg: 600-900mg/day
        • 25-34.99kg: 900-1200mg/day
        • 35-44.99kg: 900-1500mg/day
        • 45-49.99kg: 1200-1500mg/day
        • 50-59.99kg: 1200-1800mg/day
        • 60-69.99kg: 1200-2100mg/day
        • 70kg: 1500-2100mg/day
    • Initial monotherapy: PO 300mg BD, increased by 300mg/day every 3 days
  • Trigerminal neuralgia (Off-label):
    • PO 300mg BD, may increase by 600mg/day weekly
    • Dose range: 450-1200mg BD
  • Bipolar disorder (Off-label):
    • Initially PO 300mg/day and increased by 300mg/day every 3 days or by 600mg/day every week
    • Dose range: 600-1200mg BD
    • May titrate to 1800-2400mg/day maximum
  • Diabetic neuropathy (Off-label):
    • PO 150-300mg/day initially increased to 900-1200mg/day
  • Tablet:
    • 300mg
    • 600mg
  • Suspension:
    • 60mg/mL
  • Mix drawn suspension in a small glass of water just prior to administration or may be swallowed directly from the syringe
  • To be taken with/without food

Anticonvulsant

It blocks voltage-sensitive Na channels, stabilizes neural membranes, inhibits repetitive firing and decreases synaptic impulse propagation

  • Dizziness
  • Headache
  • Nausea
  • Vomiting
  • Somnolence
  • Diplopia
  • Balance disorder
  • Fatigue
  • Asthenia
  • Tremor
  • Hyponatremia
  • Visual disturbance
  • Nystagmus
  • Ataxia
  • Abnormal gait
  • Abdominal pain
  • Dyspepsia
  • Gastritis
  • Diarrhea
  • Constipation
  • Cognitive dysfunction
  • Impaired concentration
  • Confusion
  • URI symptoms
  • Rash
  • Nervousness
  • Insomnia
  • Acne
  • Photosensitivity
  • Hypersensitivity to eslicarbazepine acetate
  • HLA-B*1502 allele (treatment-naive patients)
  • Abrupt withdrawal
  • Artemether/lumefantrine
  • Cariprazine
  • Cobimetinib
  • Dienogest/estradiol valerate
  • Doravirine
  • Elbasvir/grazoprevir
  • Elvitegravir/cobicistat/emtricitabine/tenofovir df
  • Eslicarbazepine acetate
  • Ledipasvir/sofosbuvir
  • Lumacaftor/ivacaftor
  • Lumefantrine
  • Lurasidone
  • Naloxegol
  • Ombitasvir/paritaprevir/ritonavir & dasabuvir (dsc)
  • Panobinostat
  • Praziquantel
  • Regorafenib
  • Rilpivirine
  • Roflumilast
  • Vandetanib

                          Drug Status

Availability Prescription only
Pregnancy Category C
Breastfeeding Weigh risk vs benefit
Schedule Controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Trileptal 300mg Tablet 50’s Novartis Pharma Novartis Kenya
Trileptal 600mg Tablet 50’s Novartis Pharma Novartis Kenya
Trileptal 60mg/mL Suspension 100mL Novartis Pharma Novartis Kenya