- Major depressive disorder:
- PO 15mg every night at bedtime
- Max: 45mg/day
- Post-traumatic stress disorder (Off-label):
- PO 15mg every night at bedtime
- May increase no more frequently than every 1-2 weeks
- Max: 60 mg OD
- Hot flashes (Off-label):
- PO 5-60mg OD
- PO 5-60mg OD
- Insomnia (Off-label):
- PO 15-45mg every night at bedtime
- Tablet:
- 15mg
- 30mg
Taken without regards to meals
Tricyclic antidepressant
It antagonizes alpha-2 adrenergic and serotonin 5-HT2 receptors
- Somnolence
- Xerostomia
- Increased appetite
- Hypercholesterolemia
- Constipation
- Weight gain
- Asthenia
- Dizziness
- Hypertriglyceridemia
- Influenza-like symptoms
- Abnormal dreams
- Abnormal thinking
- Tremor
- Confusion
- Peripheral edema
- Elevated ALT/AST
- Myalgia
- Back pain
- Urinary frequency
- Photosensitivity
- Sleepwalking
- Hypersensitivity to class/components
- MAO inhibitor use w/in 14 days
- Abrupt withdrawal
WARNING
- Increased suicidality risk in peds and young adult patients in short-term studies
- Isocarboxazid
- Linezolid
- Methylene blue injection
- Phenelzine
- Pimozide
- Safinamide
- Selegiline
- Thioridazine
- Tranylcypromine
Drug Status
Availability | Prescription only |
Pregnancy | Category C |
Breastfeeding | Use with caution |
Schedule | Controlled |
BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
---|---|---|---|---|---|
Mirtaz | 15mg | Tablet | 30’s | Sun Pharma | Sun Pharma |
Mirtaz | 30mg | Tablet | 30’s | Sun Pharma | Sun Pharma |