• Major depressive disorder:
    • PO 15mg every night at bedtime
    • Max: 45mg/day
  • Post-traumatic stress disorder (Off-label):
    • PO 15mg every night at bedtime
    • May increase no more frequently than every 1-2 weeks
    • Max: 60 mg OD
  • Hot flashes (Off-label):
    • PO 5-60mg OD
  • Insomnia (Off-label):
    • PO 15-45mg every night at bedtime
  • Tablet:
    • 15mg
    • 30mg

Taken without regards to meals

Tricyclic antidepressant

It antagonizes alpha-2 adrenergic and serotonin 5-HT2 receptors

  • Somnolence
  • Xerostomia
  • Increased appetite
  • Hypercholesterolemia
  • Constipation
  • Weight gain
  • Asthenia
  • Dizziness
  • Hypertriglyceridemia
  • Influenza-like symptoms
  • Abnormal dreams
  • Abnormal thinking
  • Tremor
  • Confusion
  • Peripheral edema
  • Elevated ALT/AST
  • Myalgia
  • Back pain
  • Urinary frequency
  • Photosensitivity
  • Sleepwalking
  • Hypersensitivity to class/components
  • MAO inhibitor use w/in 14 days
  • Abrupt withdrawal

WARNING

  • Increased suicidality risk in peds and young adult patients in short-term studies
  • Isocarboxazid
  • Linezolid
  • Methylene blue injection
  • Phenelzine
  • Pimozide
  • Safinamide
  • Selegiline
  • Thioridazine
  • Tranylcypromine

                          Drug Status

Availability Prescription only
Pregnancy Category C
Breastfeeding Use with caution
Schedule Controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Mirtaz 15mg Tablet 30’s Sun Pharma Sun Pharma
Mirtaz 30mg Tablet 30’s Sun Pharma Sun Pharma