- Partial seizures:
- 3-12 years:
- PO 10-15mg/kg/day divided TDS initially
- Titrate up in approximately 3 days to effective maintenance dose
- 3-12 years:
-
- 3-4 years (maintenance dose):
- PO 40mg/kg/day divided TDS
- PO 40mg/kg/day divided TDS
- 3-4 years (maintenance dose):
-
- 5-12 years (maintenance dose):
- PO 25-35mg/kg/day divided TDS
- PO 25-35mg/kg/day divided TDS
- 5-12 years (maintenance dose):
-
- >12 years (initial dose):
- PO 300mg TDS
- May increase up to PO 600mg TDS
- >12 years (initial dose):
-
- Adults:
- Initially PO 300mg TDS
- May increase up to PO 600mg TDS
- Adults:
- Postherpetic neuralgia:
- PO 300mg OD day 1, then 300mg BD day 2, then 300mg TDS day 3
- Max: 1800mg/day
- Peripheral neuropathic pain (Off-label):
- PO 300mg OD day 1, then 300mg OD BD day 2, then 300mg TDS
- Max 3600mg/day
- Restless legs syndrome (Off label):
- PO 100-300mg 2 hours before bedtime on day 1
- May titrate every 2 weeks until symptom relieve achieved
- Range: 300-1800mg/day
- Insomnia (Off label):
- PO 1800mg nocte for up to 9/52
- PO 1800mg nocte for up to 9/52
- Tremors in multiple sclerosis (Off label):
- PO 1200-1800mg/day as monotherapy
- PO 1200-1800mg/day as monotherapy
- Hot flushes in breast cancer patients (Off label):
- PO 300mg TDS
- Alcohol dependence (Off label):
- PO 300mg OD day 1, then 300mg OD BD day 2, then 300mg TDS
- Max 3600mg/day
- Capsule:
- 100mg
- 150mg
- 300mg
None remarkable
GABA analog
The exact mechanism of action unknown but is thought to block the voltage-dependent calcium channels, modulating excitatory neurotransmitter release
- Dizziness
- Somnolence
- Ataxia
- Fatigue
- Fever
- Peripheral edema
- Nystagmus
- Nausea
- Vomiting
- Hostility (peds patients)
- Tremor
- Diplopia
- Asthenia
- Diarrhea
- Infection
- Xerostomia
- Emotional lability (peds patients)
- Amblyopia
- Headache
- Constipation
- Hyperkinesia (peds patients)
- Abnormal thinking
- Weight gain
- Dysarthria
- Dyspepsia
- Amnesia
- Back pain
- Depression
- Impotence
- Hypersensitivity to components
- Amifampridine
- Bupropion
- Dalfampridine
- Metoclopramide
Drug Status
| Availability | Prescription only |
| Pregnancy | Category B3; Not recommended |
| Breastfeeding | Use with caution |
| Schedule | Controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Column 1 Value | Column 2 Value | Column 3 Value | Column 4 Value | Column 5 Value | Column 6 Value |