- ICU sedation:
- Loading dose: IV 1mcg/kg over 10 minutes
- Maintenance: 0.2-0.7mcg/kg/hr continuous IV infusion. Max 24 hours
- Procedural sedation:
- Loading dose:IV 1mcg/kg over 10 minutes
- Maintenance: 0.6mcg/kg/hr titrate to effect (usually 0.2-1mcg/kg/hr)
- Schizophrenia or bipolar disorder-associated agitation:
- Mild-moderate: 120mcg bucally/sublingual *1. Max 180mcg/day
- Severe: 180mcg bucally/sublingual *1. Max 360mcg/day
- Injection:
- 100mg/mL
- Sublingual tablet:
- 120mg
- 180mg
- Loading dose infused over 10 minutes
- For the infusion, use components made with synthetic or coated natural rubber gaskets
Alpha-2 agonist sedative
It activates G-proteins in the brainstem causing an in inhibition of norepinephrine release. It also activates presynaptic alpha-2 adrenergic receptors
- Somnolence
- Orthostatic hypotension
- Paresthesia
- Oral hypoesthesia
- Xerostomia
- Dizziness
- Hypotension
- Nausea
- Bradycardia
- Abdominal discomfort
- Hypersensitivity to class/components
- Hypotension
- Orthostatic hypotension
- Advanced heart block
- Severe ventricular dysfunction
- Syncope history
- Electrolyte abnormalities
- Congenital long QT syndrome
- QT prolongation
- Torsades de pointes history
- Ventricular arrhythmia
- Bradycardia
- Recent MI
- CHF
- Cisapride
- Levoketoconazole
- Pimozide
- Thioridazine
Drug Status
| Availability | Prescription only |
| Pregnancy | Category C |
| Breastfeeding | Can be used |
| Schedule | Controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Coming soon | Coming soon | Coming soon | Coming soon | Coming soon | Coming soon |