- Schizophrenia and other psychotic disorders:
- PO 25mg TDS or 75mg nocte. Maintenance: 75mg-300mg/day. Max 1g
- IM 25 mg initially, then 25-50 mg PRN after 1-4 hours. Increased to maximum of 400 mg every 4-6hrs until patient is controlled. Maintenance 300-800 mg/day.
- Nausea & vomiting (where other drugs have failed especially in terminal illness):
- PO 25 mg every 4-6 hours PRN
- IM 25-50 mg every 4-6 hours PRN
- Preoperative sedation:
- PO 25-50mg 2-3 hours before procedure
- IM 12.5-25 mg 1-2 hours before procedure
- Intractable hiccups:
- PO 25-50mg TDS/QID
- If they persist more than 2-3 days, administer IM 25-50mg*1
- Acute intermittent porphyria:
- PO 25-50 mg PO TDS/QID
- Adjunctive treatment of tetanus:
- IM/IV 25-50 mg every 6-8hours
Tablet: 25mg, 100mg
Injection: 25mg/ml
- Consider discontinuation in unexplained decrease of WBCs.
- Can be taken with or without food.
- IV infusion is only for adjunctive treatment of intractable hiccups in adults
Phenothiazine antipsychotic.
It is thought to selectively antagonize dopamine D2 receptors in the brain.
- Extrapyramidal symptoms such as dystonia, muscle stiffness, parkisonism, tardive dyskinesia
- Drowsiness
- Hypotension
- Blurred vision
- Xerostomia
- Constipation
- Urinary retention
- Nasal congestion
- Hyperprolactinemia
- Sexual dysfunction
- Weight gain
- Oligomenorrhea
- Amenorrhea
- Risk of death in patients with dementia-related psychosis
- Hypersensitivity to class/compound
- Severe CVS disease
- Neonates
- Comatose patients
- Close angle glaucoma
- BM depression
- Reye’s syndrome
- Parkisonism
- Myasthenia gravis
- Hyperthyroidism
- Lactation
- DM
- Subcortical brain damage
- Procainamide
- Sotalol
- Metoclopramide
- Guanithidine
- Anti-muscarinics
- Quinidine
- Indapamide
- Pentamidine
Drug Status
| Availability | Prescription only |
| Pregnancy | Category C |
| Breastfeeding | Contraindicated |
| Schedule | Controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Chlorpromazine | 25mg/2mL | Injection | 1’s | Laborate India | Harley’s Ltd |
| Chlorpromazine | 100mg | Tablet | 100’s | Laboratory & Allied | Laboratory & Allied |
| Chlorpromazine | 25mg | Tablet | 100’s | Laboratory & Allied | Laboratory & Allied |
| Chlorpromazine | 100mg | Tablet | 100’s | Elys Chemicals | Elys Chemicals |
| Chlorpromazine | 25mg/mL | Injection | 1’s | Laboratory & Allied | Laboratory & Allied |
| Chlorpromazine | 100mg | Tablet | 100’s | Cosmos Ltd | Cosmos Ltd |
| Chlorpromazine | 25mg | Tablet | 100’s | Cosmos Ltd | Cosmos Ltd |
| Chlorpromazine | 25mg | Tablet | 100’s, 1000’s | Biodeal Labs | Biodeal Labs |
| Chlorpromazine | 100mg | Tablet | 100’s, 1000’s | Biodeal Labs | Biodeal Labs |
| Chlorpromed | 50mg/2mL | Injection | 1’s | Dawa Ltd | Dawa Ltd |
| Medizine | 100mg | Tablet | 100’s | Medisel Kenya | Medisel Kenya |