- Hyperchlostestoremia:
- 10mg/10mg – 10mg/40mg OD nocte
- May start 10mg/40mg in patients with >55% LDL reduction goal
- Max 10mg/40mg per day
- Mixed dyslipidemia:
- 10mg/10mg – 10mg/20mg OD nocte
- May start 10mg/40mg in patients with >55% LDL reduction goal
- Max 10mg/40mg per day
- Tablet:
- 10mg/10mg
- 10mg/20mg
- 10mg/40mg
- Patient should be on a standard cholesterol-lowering diet before receiving drug
- Administer >2 hours before or >4 hours after bile acid sequestrant
Ezetimibe: Lipid-lowering agent. It inhibits cholesterol absorption at small intestine brush border, decreasing hepatic cholesterol stores and increasing blood cholesterol clearance
Simvastatin: HMG-CoA reductase inhibitor. It inhibits the rate-limiting step in cholesterol biosynthesis by competitively inhibiting HMG-CoA reductase
- Headache
- URI
- Diarrhea
- Abdominal pain
- Constipation
- Gastritis
- Nausea
- Eczema
- Arthralgia
- Myalgia
- Diabetes mellitus
- Dizziness
- Fatigue
- Insomnia
- Back pain
- Extremity pain
- Elevated creatine
- Elevated ALT/AST
- UTI
- Edema
- Cough
- Cognitive impairment
- Hypersensitivity to class/components
- Pregnancy (non-high risk patients)
- Myopathy
- Unexplained elevated LFTs
- Active hepatic disease
- Atazanavir
- Ceritinib
- Clarithromycin
- Cobicistat
- Cyclosporine
- Darunavir
- Erythromycin
- Fosamprenavir
- Gemfibrozil
- Idelalisib
- Ketoconazole
- Levoketoconazole
- Lonafarnib
- Lopinavir/ritonavir
- Nefazodone
- Posaconazole
- Ribociclib
- Ritonavir
- Saquinavir
- Tipranavir
- Tucatinib
- Voriconazole
Drug Status
| Availability | Prescription only |
| Pregnancy | Category X |
| Breastfeeding | Contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Inegy | 10mg/10mg | Tablet | 28’s | MSD Ltd | Imperial Managed |
| Inegy | 10mg/20mg | Tablet | 28’s | MSD Ltd | Imperial Managed |
| Inegy | 10mg/40mg | Tablet | 28’s | MSD Ltd | Imperial Managed |