• Acute anterior wall myocardial infarction:
    • Initially PO 7.5mg BD*2/7, then 15mg BD *2/7, then 30mg BD
    • Target dose: 30mg BD
    • Begin 24 hours after onset of symptoms and continue dose for 6/52
  • Hypertension:
    • Initially PO 15mg OD
    • May increase dose at 4-week intervals
    • Usual effective dose: PO 30mg OD
    • Maximum daily dose: 60 mg/day, administer OD or divided BD
  • Tablet:
    • 30mg
  • Can be taken with or without food
  • Diuretics should be discontinued 2-3 days prior to initiating zofenopril, if possible.
  • Restart diuretic after blood pressure is stable, if needed.
  • If diuretic can be discontinued prior to therapy, begin with 15mg/day with close supervision until stable blood pressure.
  • Start dose at 7.5mg/day if these measures cannot be taken.

ACE Inhibitor.

It acts primarily on the suppression of the plasma renin-angiotensin aldosterone system thus decreasing plasma angiotensin II concentration, leading to decreased vasopressor activity and reduced aldosterone secretion

  • 1st-dose hypotension
  • Symptomatic hypotension
  • Increased blood urea and creatinine concentration
  • Hyperkalaemia
  • Cholestatic jaundice
  • Cough
  • Neutropenia
  • Agranulocytosis
  • Thrombocytopenia
  • Anaemia
  • Proteinuria
  • Marked elevation of liver enzymes
  • Hypersensitivity to class/ingredients
  • History of angioneurotic oedema associated with previous ACE inhibitor therapy.
  • Hereditary/idiopathic angioneurotic oedema.
  • Severe hepatic impairment
  • Women of child-bearing potential unless protected by effective contraception.
  • Bilateral renal artery stenosis or unilateral renal artery stenosis in cases of a solitary single kidney
  • Pregnancy
  • Diabetes
  • Sacubitril/valsartan
  • Racecadotril
  • Sirolimus
  • Everolimus
  • Temsirolimus
  • Potassium-sparing diuretics
  • Aliskiren

                                   Drug Status

Availability Prescription only
Pregnancy Contraindicated
Breastfeeding Contraindicated
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Bifril 30mg Tablet 28’s Menarini International Phillips Therapeutics