- Cardiovascular death prevention:
- 60mg BD
- Stroke in acute coronary syndrome (ACS):
- Loading dose (following ACS event): 180 mg x 1 dose; then 90mg BD *12 months, then 60mg BD as maintenance
- Give with daily maintenance dose of aspirin 75-100 mg
- Use of aspirin >100mg decreases effectiveness of ticagrelor
- Coronary artery disease:
- 60mg BD
- For patients without history of stroke/MI, give with aspirin 75-100mg
- Acute ischaemic stroke/Transient ischemic attack:
- Loading dose: 180mg x 1dose then 90mg BD up to 30 days
- Use with loading dose of aspirin (300-325mg) and daily maintenance dose of 75-100mg
Tablet: 90mg
- Hold treatment 5 days before start of major surgery
- Restart as soon as possible
Platelet aggregation inhibitor
It reversibly binds to P2Y12 adenosine diphosphate receptors, reducing platelet activation and aggregation. Superior to clopidogrel
- Dyspnea
- Bleeding
- Elevated Cr
- Dizziness
- Nausea
- Diarrhoea
- Hypersensitivity to component
- Active bleeding
- History of intracranial hemorrhage
- CABG surgery
- Severe hepatic impairment
- Itraconazole
- CYP3A inhibitors
- CYP3A inducers
Brilinta (AstraZeneca), Tiglor (Prism)
Drug Status
| Availability | Prescription only |
| Pregnancy | Category C |
| Breastfeeding | Contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Brilinta | 90mg | Tablet | 56’s | AstraZeneca | AstraZeneca |
| Grelor | 60mg | Tablet | 30’s | Medfo Kenya | Medfo Kenya |
| Grelor | 90mg | Tablet | 30’s | Medfo Kenya | Medfo Kenya |
| Tiglor | 90mg | Tablet | 30’s | Galaxy Pharma | Galaxy Pharma |