Telmisartan/ Amlodipine/ Hydrochlorothiazide

• Tablet:
  • 40mg/2.5mg/12.5mg
  • 40mg/5mg/12.5mg
  • 80mg/2.5mg/12.5mg
  • 80mg/5mg/12.5mg

• May cause dehydration hence drink a lot of water

Telmisartan: Angiotensin II receptor antagonist (ARB). It binds to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a reduction in arterial blood pressure.

Amlodipine: Dihydropyridine calcium channel blocker. It inhibits the influx of calcium ions into both vascular smooth muscle and cardiac muscle. The contraction of cardiac muscle and vascular smooth muscle are dependent on the movement of extracellular calcium ions into these cells by specific ion channels. It is also considered a peripheral arterial vasodilator that exerts its action directly on vascular smooth muscle to lead to a reduction in peripheral vascular resistance, causing a decrease in blood pressure.

Hydrochlorothiazide: Thiazide diuretic. It inhibits sodium reabsorption in distal renal tubules, resulting in increased excretion of water and of sodium, potassium and hydrogen ions.

• Sleepiness
• Ankle swelling
• Headache
• Flushing
• Dizziness
• Tiredness
• Palpitations
• Stomach upset
• Mood changes

• Hypersensitivity to class/ingredients
• Recent history of heart attack
• Kidney disease
• Liver disease
• Pregnant women or planning to get pregnant
• Breastfeeding women
• Diabetes

• Lithium
• Digoxin
• Metformin
• Sildenafil
• Simvastatin
• Enalapril
• Lisinopril
• Ramipril
• Cyclosporine
• Aliskiren