• Essential hypertension in patients with secondary hyperaldosteronism
  • Resistant oedema in patients with secondary hyperaldosteronism

Dose:

  • PO 1 tab OD
  • May be increased to 4 tabs/day

Tablet:

  • 50mg/20mg
  • 50mg/40mg
  • Best taken in the morning

Spironolactone: Potassium-sparing diuretic. It binds to mineralocorticoid receptors and promotes sodium and water excretion and potassium retention

Furosemide: Loop diuretic. It inhibits primarily the absorption of sodium and chloride in the proximal and distal tubules and in the loop of Henle

  • Gynecomastia
  • Electrolyte imbalance
  • Volume depletion
  • Children under 18 years
  • Addison’s disease
  • Anuria
  • Breastfeeding
  • Dehydration
  • Galactosaemia
  • Hyperkalaemia
  • Hypovolaemia
  • Long QT syndrome
  • Porphyria
  • Renal damage secondary to nephrotoxic agents
  • Renal impairment
  • Severe hypokalaemia
  • Severe hyponatraemia
  • Torsade de pointes
  • Amlodipine
  • Valsartan
  • Amiodarone
  • Olmesartan

                                   Drug Status

Availability Prescription only
Pregnancy Contraindicated
Breastfeeding Contraindicated
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Spiromide 50mg/20mg Tablet 20’s The Searle Company Globe Pharmacy
Spiromide 50mg/40mg Tablet 30’s The Searle Company Globe Pharmacy