Riociguat

Tablet:

• 5mg
• 1mg
• 5mg
• 2mg
• 5mg

• May be crushed and mixed with soft foods just before taking

It is a stimulator of soluble guanylate cyclase (sGC), an enzyme in the cardiopulmonary system and the receptor for nitric oxide (NO).

It sensitizes and stimulates the binding of soluble guanylate cyclase (sGC) to nitric oxide in nitric oxide-sGC-cGMP pathway, increasing cGMP production and subsequent vasodilation.

• Headache
• Gastritis
• Dyspepsia
• Dizziness
• Nausea
• Diarrhea
• Hypotension
• Vomiting
• Anemia
• GERD
• Constipation

• Hypersensitivity to drug or ingredient
• Pregnancy; Avoid pregnancy by using 2 forms of effective contraception (1 must be non-hormonal) during treatment and 1 month after discontinuation in female patients
• Breastfeeding
• Pulmonary veno-occlusive disease
• Idiopathic interstitial pneumonia

WARNING

Contraindicated in pregnant females because it may cause fetal harm

• Amyl nitrite
• Avanafil
• Dipyridamole
• Isosorbide dinitrate
• Isosorbide mononitrate
• Nitroglycerin
• Sildenafil
• Tadalafil
• Theophylline
• Vardenafil
• Vericiguat
• Aminophylline
• Nitric oxide
• Nitroprusside