- Hypertension:
- On diuretic: initially 1.25mg OD
- Without diuretic: initially 25mg OD
- Maintenance: PO 5-20mg/day OD or divided BD
- Decreased efficacy as monotherapy in Black patients, consider combination treatment
- Post-MI heart failure:
- PO 2.5mg BD, then increase dose every 3 weeks to 5mg BD
- Maintenance: 5mg BD
- Can start with 1.25mg OD if hypovolemia or renal artery stenosis
- Cardiovascular event risk reduction in patients ≥55 years:
- PO 2.5mg OD *1/52, then 5mg OD *3 weeks, then 10mg OD
- Maintenance: 10mg BD
- For hypertensive or recently post-MI patients, give 5mg BD
- Can start with 1.25mg OD if hypovolemia or renal artery stenosis
- Heart failure with reduced ejection fraction:
- Initially PO 1.25-2.5mg OD
- Max: 10mg/day
- Diabetic nephropathy (Off-label):
- Initial (not on diuretic): 5mg OD
- Initial (with diuretic): 25mg OD
- Maintenance: 5-20 mg OD
- Tablet:
- 2.5mg
- 5mg
- 10mg
Taken without regard to food
Angiotensin converting enzyme (ACE) inhibitor
It dilates arteries and veins by competitively inhibiting the conversion of angiotensin I to angiotensin II (a potent endogenous vasoconstrictor) and by inhibiting bradykinin metabolism resulting in preload and afterload reductions on the heart
- Cough
- Hypotension
- Dizziness
- Fatigue
- Hyperkalemia
- Nausea
- Vomiting
- Elevated BUN or Cr
- Photosensitivity
- Hyperuricemia
- Hypersensitivity to drug or other ACE inhibitors
- Hereditary, idiopathic, ACE inhibitor-associated history of angioedema
WARNING:
Fetal/neonatal morbidity/mortality may occur
- Aliskiren
- Protein a column
- Sacubitril/valsartan
Drug Status
Availability | Prescription only |
Pregnancy | Category D |
Breastfeeding | Contraindicated |
Schedule | Not controlled |
BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
---|---|---|---|---|---|
Ramitace | 2.5mg | Tablet | 30’s | Biodeal Labs | Biodeal Labs |
Ramitace | 5mg | Tablet | 30’s | Biodeal Labs | Biodeal Labs |
Ramitace | 10mg | Tablet | 30’s | Biodeal Labs | Biodeal Labs |
Ramitas | 2.5mg | Capsule | 30’s | Intas Pharma | Accord Healthcare |
Ramitas | 5mg | Capsule | 30’s | Intas Pharma | Accord Healthcare |
Tritace | 2.5mg | Tablet | 28’s | Sanofi-Aventis | Ressourcethica Kenya |
Tritace | 5mg | Tablet | 28’s | Sanofi-Aventis | Ressourcethica Kenya |