• Hypertension:
    • On diuretic: initially 1.25mg OD
    • Without diuretic: initially 25mg OD
    • Maintenance: PO 5-20mg/day OD or divided BD
    • Decreased efficacy as monotherapy in Black patients, consider combination treatment
  • Post-MI heart failure:
    • PO 2.5mg BD, then increase dose every 3 weeks to 5mg BD
    • Maintenance: 5mg BD
    • Can start with 1.25mg OD if hypovolemia or renal artery stenosis
  • Cardiovascular event risk reduction in patients ≥55 years:
    • PO 2.5mg OD *1/52, then 5mg OD *3 weeks, then 10mg OD
    • Maintenance: 10mg BD
    • For hypertensive or recently post-MI patients, give 5mg BD
    • Can start with 1.25mg OD if hypovolemia or renal artery stenosis
  • Heart failure with reduced ejection fraction:
    • Initially PO 1.25-2.5mg OD
    • Max: 10mg/day
  • Diabetic nephropathy (Off-label):
    • Initial (not on diuretic): 5mg OD
    • Initial (with diuretic): 25mg OD
    • Maintenance: 5-20 mg OD
  • Tablet:
    • 2.5mg
    • 5mg
    • 10mg

Taken without regard to food

Angiotensin converting enzyme (ACE) inhibitor

It dilates arteries and veins by competitively inhibiting the conversion of angiotensin I to angiotensin II (a potent endogenous vasoconstrictor) and by inhibiting bradykinin metabolism resulting in preload and afterload reductions on the heart

  • Cough
  • Hypotension
  • Dizziness
  • Fatigue
  • Hyperkalemia
  • Nausea
  • Vomiting
  • Elevated BUN or Cr
  • Photosensitivity
  • Hyperuricemia
  • Hypersensitivity to drug or other ACE inhibitors
  • Hereditary, idiopathic, ACE inhibitor-associated history of angioedema

WARNING:

Fetal/neonatal morbidity/mortality may occur

  • Aliskiren
  • Protein a column
  • Sacubitril/valsartan

                                   Drug Status

Availability Prescription only
Pregnancy Category D
Breastfeeding Contraindicated
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Ramitace 2.5mg Tablet 30’s Biodeal Labs Biodeal Labs
Ramitace 5mg Tablet 30’s Biodeal Labs Biodeal Labs
Ramitace 10mg Tablet 30’s Biodeal Labs Biodeal Labs
Ramitas 2.5mg Capsule 30’s Intas Pharma Accord Healthcare
Ramitas 5mg Capsule 30’s Intas Pharma Accord Healthcare
Tritace 2.5mg Tablet 28’s Sanofi-Aventis Ressourcethica Kenya
Tritace 5mg Tablet 28’s Sanofi-Aventis Ressourcethica Kenya