- Hypotension/shock:
- IV bolus 100-500mcg/dose every 10 to 15 minutes as needed
- Initial dose should not exceed 500mcg
- IV bolus 100-500mcg/dose every 10 to 15 minutes as needed
-
- IV infusion initially 100-180mcg/min OR5mcg/kg/minute
- Titrate to desired response.
- IV infusion initially 100-180mcg/min OR5mcg/kg/minute
- For initial vasoactive management of cardiogenic shock due to aortic stenosis, mitral stenosis or dynamic left ventricular outflow tract (LVOT) obstruction (Off-label):
- IV 0.1-10mcg/kg/minute
- Initially dose 0.5-2mcg/kg/minute, titrated to effect
- Initially dose 0.5-2mcg/kg/minute, titrated to effect
- IV 0.1-10mcg/kg/minute
- Hypotension during anesthesia:
- IV bolus 40-100mcg/dose every 1-2 minutes as needed
- Max: 200mcg
- Max: 200mcg
- IV bolus 40-100mcg/dose every 1-2 minutes as needed
-
- IV infusion initially 10-35mcg/minute adjusted according to blood pressure goal
- Not to exceed 200mcg/minute
- IV infusion initially 10-35mcg/minute adjusted according to blood pressure goal
- Post-resuscitation stabilization (Off-label)
- IV 0.5-2mcg/kg/min
- IV 0.5-2mcg/kg/min
- Rapid sequence intubation adjunct (Off-label)
- IV 50-100mcg *1
- Max: 200mcg/total dose
- For patients with shock or symptomatic hypotension during intubation
- IV 50-100mcg *1
- Priapism (Off-label):
- 1mL (100-500mcg/mL) intracavernously every 3-5min for up to 1h
- Max: 1000mcg/h
- Dilute with normal saline to conc. 100-500mcg/mL
- Use lower conc. or volume in patients with severe CVD
- Pre-filled syringe:
- 50mcg/mL
- Bolus: Administer every 1-2 minutes as needed
- Continuous IV infusion: Start infusion rate of 10-35mcg/min; not to exceed 200mcg/min
- If extravasation occurs:
- Stop infusion immediately and disconnect (leave cannula/needle in place)
- Gently aspirate extravasated solution (do not flush the line)
- Remove needle/cannula
- Elevate extremity.
- Initiate phentolamine (or alternative antidote)
- Apply dry warm compresses
Alpha-Adrenergic Agonist
It causes increased peripheral vascular resistance and blood pressure and decreases cardiac output and renal perfusion
- Headache
- Dizziness
- CNS stimulation
- Anxiety
- Palpitations
- Reflex bradycardia
- HTN
- Arrhythmia
- Tremor
- Diaphoresis
- Nausea
- Vomiting
- Pruritus
- Hypersensitivity to drug or ingredient
- Severe hypertension
- Ventricular tachycardia
- Dihydroergotamine
- Isocarboxazid
- Phenelzine
- Iobenguane I 123
- Linezolid
- Procarbazine
- Selegiline transdermal
- Tranylcypromine
Drug Status
Availability | Prescription only |
Pregnancy | Contraindicated |
Breastfeeding | Contraindicated |
Schedule | Not controlled |
BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
---|---|---|---|---|---|
Phenylephrine | 50mcg/mL | Pre-Filled Syringe | 10mL*10’s | Laboratoire Renaudin | Phillips Therapeutics |