• Angina:
    • Transdermal: 1 patch OD
      • May be applied to any skin surface, except on extremities below the knees or elbows
      • Nitrate-free period of 10-12 hours duration (overnight) needed to prevent tolerance
    • Injection: Initially IV 5mcg/min
      • May be increased by 5mcg/min every 3-5min until response or 20mcg/min IV
      • If no response, then may increase by 10-20mcg/min every 3-5min
      • Use if unresponsive to SL NTG and beta blockers
  • Angina prophylaxis:
    • PO 2.6mg-6.4mg every 6-8 hours
  • Hypertension:
    • IV 5mcg/min
    • May increase by 5mcg/min every 3-5min until response OR 20mcg/min
    • If no response, then may increase by 10-20mcg/min every 3-5min
  • Post-MI heart failure:
    • IV 5mcg/min
    • May increase by 5mcg/min every 3-5min until response OR 20 mcg/min IV
    • If no response, then may increase by 10-20mcg/min every 3-5min
  • Tablet:
    • 2.6mg
    • 6.4mg
  • Transdermal patch:
    • 5mg
    • 10mg
    • 15mg

None remarkable

Organic nitrate

It stimulates cGMP production, resulting in vascular smooth muscle relaxation

  • Headache
  • Dizziness
  • Paresthesia
  • Weakness
  • Flushing
  • Rash
  • Orthostatic hypotension
  • Hypersensitivity
  • Recent use (within several days) of PDE-5 inhibitors (e.g, avanafil, sildenafil, tadalafil, or vardenafil) (PO)
  • Acute MI (PO)
  • Severe anemia
  • Increased ICP
  • Circulatory collapse
  • Shock
  • Pericardial tamponade (IV use)
  • Restrictive cardiomyopathy (IV use)
  • Constrictive pericarditis (IV use)
  • Avanafil
  • Lidocaine topical
  • Prilocaine topical
  • Riociguat
  • Sildenafil
  • Tadalafil
  • Vardenafil

                          Drug Status

Availability Prescription only
Pregnancy Category C
Breastfeeding Not recommended
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Nitrocontin 2.6mg Tablet 25’s Modi Mundipharma Europa Healthcare
Nitrocontin 6.4mg Tablet 25’s Modi Mundipharma Europa Healthcare