• Chronic stable angina:
    • PO 10mg BD
  • Tablet:
    • 10mg
  • Can be taken with or without food.

It opens KATP channels relaxing the vascular muscles, decreasing vaso-resistance and blood pressure thus relieving the pain and at the same time protecting myocardium against ischemia.

It also causes the relaxation of coronary vascular smooth muscles by inhibiting guanylyl cyclase and increasing cyclic GMP levels with the activation of K+ channels and hyperpolarization through a second mechanism.

  • Headache
  • Nausea
  • Vomiting
  • Dizziness
  • Weakness
  • Flushing
  • Uneven heartbeat
  • Hypersensitivity to class/ingredients
  • Hypotension
  • Children under 18 years
  • Acute pulmonary oedema
  • Breastfeeding
  • Cardiogenic shock
  • Hypovolemia
  • Left ventricular dysfunction
  • Vardenafil
  • Sildenafil
  • Tadalafil
  • Riocigaut
  • Dapoxetine
  • Aspirin
  • Prednisolone
  • Lisinopril
  • Ramipril
  • Losartan
  • Valsartan
  • Candesartan

                                   Drug Status

Availability Prescription only
Pregnancy Contraindicated
Breastfeeding Contraindicated
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Ikorel 10mg Tablet 60’s Sanofi Aventis Surgipharm Ltd