- HTN
- Mild to moderate heart failure
5mg OD. May be increased every 2 weeks. Max 40mg/day
- Tablet:
- 2.5mg
- 5mg
- 10mg
- To be taken without regard to food once a day.
- Avoid abrupt withdrawal
- Dose tapered over 1-2 weeks.
Selective B1 antagonist.
It blocks beta-1 adrenergic receptors leading to decreased resting heart rate, myocardial contractility, systolic and diastolic blood pressure. It is also responsible for beta-3 adrenergic receptor agonist activity that includes stimulating endothelial nitric oxide synthase thereby increasing nitric oxide levels. This consequently leads to vasodilation, decreased peripheral vascular resistance, increased stroke volume, ejection fraction and cardiac output, beneficial to patients with heart failure.
- Headache
- Fatigue
- Dizziness
- Nausea
- Severe bradycardia
- Insomnia
- Diarrhoea
- Peripheral oedema
- Hypersensitivity to components
- Severe hepatic failure
- Sinus bradycardia
- 2nd or 3rd degree AV block
- Cardiogenic shock
- Decompensated heart failure
- Atenolol
- Carvedilol
- Verapamil
- Inhaled albuterol
Drug Status
| Availability | Prescription only |
| Pregnancy | Category C |
| Breastfeeding | Contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Nebi | 2.5mg | Tablet | 30’s | Galaxy Pharma | Galaxy Pharma |
| Nebi | 5mg | Tablet | 30’s | Galaxy Pharma | Galaxy Pharma |
| Nebicard | 2.5mg | Tablet | 30’s | Torrent Pharma C/O Medox | Medox Pharma |
| Nebicard | 5mg | Tablet | 30’s | Torrent Pharma C/O Medox | Medox Pharma |
| Nebiem | 2.5mg | Tablet | 30’s | MSN Labs | Simba Pharma |
| Nebiem | 5mg | Tablet | 30’s | MSN Labs | Simba Pharma |
| Nebilet | 5mg | Tablet | 28’s | Menarini International | Phillips Therapeutics |
| Nebiloc-2.5 | 2.5mg | Tablet | 30’s | Universal Corporation | Universal Corporation |
| Nebiloc-5 | 5mg | Tablet | 30’s | Universal Corporation | Universal Corporation |
| Nebilong | 5mg | Tablet | 30’s | Micro Labs | Micro Labs |
| Nebilong | 10mg | Tablet | 30’s | Micro Labs | Micro Labs |
| Nebilong | 2.5mg | Tablet | 30’s | Micro Labs | Micro Labs |
| Nebiring | 2.5mg | Tablet | 30’s | Ravenbhel Healthcare | Synermed Pharma |
| Nebiring | 5mg | Tablet | 30’s | Ravenbhel Healthcare | Synermed Pharma |
| Nebiton | 2.5mg | Tablet | 30’s | Medisel Kenya | Medisel Kenya |
| Nebiton | 5mg | Tablet | 30’s | Medisel Kenya | Medisel Kenya |
| Nebivas | 5mg | Tablet | 30’s | Innocia Lifesciences | Wessex Pharma |
| Nebivas | 10mg | Tablet | 30’s | Innocia Lifesciences | Wessex Pharma |
| Nebtas | 5mg | Tablet | 30’s | Intas Pharma | Accord Healthcare |
| Nebtas | 10mg | Tablet | 30’s | Intas Pharma | Accord Healthcare |
| Nodon | 10mg | Tablet | 30’s | Cadila Pharm | Cadila Pharm |
| Nodon | 5mg | Tablet | 30’s | Cadila Pharm | Cadila Pharm |