• Hypertension:
    • 1-2 tabs OD

Tablet:

  • 10mg/12.5mg
  • 20mg/12.5mg
  • Should NOT be used as initial therapy
  • Best taken in the morning due to the diuresis effect of hydrochlorothiazide (peaks in 4 hours)

Lisinopril: ACEI

Hydrochlorothiazide: Thiazide diuretic

  • Dizziness
  • Hypotension
  • Persistent dry cough
  • Voice changes
  • Elevated BUN/Cr
  • Hyperkalemia
  • Headache
  • Renal/hepatic impairment
  • Anaphylactic reactions
  • Hyperglycemia
  • Glycosuria
  • Hyperuricaemia
  • Hyponatremia
  • Anorexia
  • Impotence
  • Postural hypotension
  • Gastric irritation
  • Nausea
  • Vomiting
  • Diarrhoea
  • Hypokalemia
  • Fatigue
  • Orthostatic hypotension
  • Hypersensitivity to ACEIs, thiazides or sulphonamides
  • Co-administration of ACEIs within 36 hours of switching to or from valsartan
  • Anuria or renal stenosis
  • Pregnancy
  • Breastfeeding (HCTZ dose >50 mg/day)
  • CrCl <30
  • Current or history of angioedema
  • Valsartan
  • Amikacin
  • Lithium
  • Erythromycin
  • Halofantrine
  • Pentamidine
  • Terfenadine
  • Mannitol

                                   Drug Status

Availability Prescription only
Pregnancy Category D
Breastfeeding Contraindicated
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Auroliza-H 10mg/12.5mg Tablet 28’s Aurobindo Pharma Simba Pharma
Zestoretic 20mg/12.5mg Tablet 28’s AstraZeneca Imperial Managed