• Hypertension:
    • 10-40mg per day. Max 40mg/day
  • CCF with reduced ejection fraction:
    • 5-40mg per day. Max 80mg/day
    • Start with 2.5-5mg
  • Acute MI:
    • 10mg OD for at least 6/52
    • Start 5mg x 1 within 24h of MI, then after 24h, 5mg x1
    • For patients with SBP 100-120, start 2.5mg OD x3 days, then may increase to usual dose
  • Diabetic nephropathy (Off-label):
    • 5mg OD initially (with diuretic)
    • May increase dose gradually

Dosing considerations in renal impairment

  • Acute MI: Use caution in renal dysfunction (serum creatinine >2mg/dL)
  • HTN and CrCl >30 mL/min: 10mg OD initially. Max 40mg/day
  • HTN and CrCl 10-30 mL/min: 5mg OD initially. Max 40mg/day
  • HTN and CrCl <10 mL/min or hemodialysis: 2.5mg OD initially. Max 40mg/day
  • CCF and CrCl <30 mL/min: 2.5mg OD initially. Max 40mg/day

Tablet: 5mg, 10mg

  • Discontinue with prolonged hypotension
  • For CCF, adjunctive therapy with diuretics and (usually) digitalis is used

ACEI

It interferes with the angiotensin converting enzyme thereby inhibiting conversion of angiotensin I to angiotensin II which is a potent vasoconstrictor, therefore dilates arteries and veins

  • Dizziness
  • Hypotension
  • Persistent dry cough
  • Voice changes
  • Elevated BUN/Cr
  • Hyperkalemia
  • Headache
  • Renal/hepatic impairment
  • Anaphylactic reactions
  • Hypersensitivity to component/class
  • History of angioedema with ACEIs
  • Angioedema
  • Pregnancy
  • Valsartan

Auroliza (Aurobindo), Lisace (Cosmos), Lisinopril (Distributed By Metro), Listril (Torrent), Zestril (AstraZeneca)

                                   Drug Status

Availability Prescription only
Pregnancy Category D
Breastfeeding Contraindicated
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Auroliza 5mg Tablet 28’s Aurobindo Pharma Simba Pharma
Auroliza 10mg Tablet 28’s Aurobindo Pharma Simba Pharma
Lisace 10mg Tablet 28’s Cosmos Ltd Cosmos Ltd
Lisace 5mg Tablet 28’s Cosmos Ltd Cosmos Ltd
Listril 10mg Tablet 100’s Torrent Pharma C/O Medox Medox Pharma
Listril 5mg Tablet 100’s Torrent Pharma C/O Medox Medox Pharma
Zestril 5mg Tablet 28’s AstraZeneca Imperial Managed
Zestril 10mg Tablet 28’s AstraZeneca Imperial Managed
Zestril 20mg Tablet 28’s AstraZeneca Imperial Managed