- Hypertension:
- 10-40mg per day. Max 40mg/day
- CCF with reduced ejection fraction:
- 5-40mg per day. Max 80mg/day
- Start with 2.5-5mg
- Acute MI:
- 10mg OD for at least 6/52
- Start 5mg x 1 within 24h of MI, then after 24h, 5mg x1
- For patients with SBP 100-120, start 2.5mg OD x3 days, then may increase to usual dose
- Diabetic nephropathy (Off-label):
- 5mg OD initially (with diuretic)
- May increase dose gradually
Dosing considerations in renal impairment
- Acute MI: Use caution in renal dysfunction (serum creatinine >2mg/dL)
- HTN and CrCl >30 mL/min: 10mg OD initially. Max 40mg/day
- HTN and CrCl 10-30 mL/min: 5mg OD initially. Max 40mg/day
- HTN and CrCl <10 mL/min or hemodialysis: 2.5mg OD initially. Max 40mg/day
- CCF and CrCl <30 mL/min: 2.5mg OD initially. Max 40mg/day
Tablet: 5mg, 10mg
- Discontinue with prolonged hypotension
- For CCF, adjunctive therapy with diuretics and (usually) digitalis is used
ACEI
It interferes with the angiotensin converting enzyme thereby inhibiting conversion of angiotensin I to angiotensin II which is a potent vasoconstrictor, therefore dilates arteries and veins
- Dizziness
- Hypotension
- Persistent dry cough
- Voice changes
- Elevated BUN/Cr
- Hyperkalemia
- Headache
- Renal/hepatic impairment
- Anaphylactic reactions
- Hypersensitivity to component/class
- History of angioedema with ACEIs
- Angioedema
- Pregnancy
- Valsartan
Auroliza (Aurobindo), Lisace (Cosmos), Lisinopril (Distributed By Metro), Listril (Torrent), Zestril (AstraZeneca)
Drug Status
Availability | Prescription only |
Pregnancy | Category D |
Breastfeeding | Contraindicated |
Schedule | Not controlled |
BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
---|---|---|---|---|---|
Auroliza | 5mg | Tablet | 28’s | Aurobindo Pharma | Simba Pharma |
Auroliza | 10mg | Tablet | 28’s | Aurobindo Pharma | Simba Pharma |
Lisace | 10mg | Tablet | 28’s | Cosmos Ltd | Cosmos Ltd |
Lisace | 5mg | Tablet | 28’s | Cosmos Ltd | Cosmos Ltd |
Listril | 10mg | Tablet | 100’s | Torrent Pharma C/O Medox | Medox Pharma |
Listril | 5mg | Tablet | 100’s | Torrent Pharma C/O Medox | Medox Pharma |
Zestril | 5mg | Tablet | 28’s | AstraZeneca | Imperial Managed |
Zestril | 10mg | Tablet | 28’s | AstraZeneca | Imperial Managed |
Zestril | 20mg | Tablet | 28’s | AstraZeneca | Imperial Managed |