• Heart failure with reduced ejection fraction, NYHA Class II-III:
    • Initially PO 5mg BD
    • Max 15mg/day
  • Tablet:
    • 5mg
    • 7.5mg

To be taken after meals

HCN Channel Blockers

It blocks hyperpolarization-activated cyclic nucleotide-gated (HCN) channel in SA node, selectively inhibiting cardiac pacemaker current to decrease the heart rate

  • Bradycardia
  • Hypertension
  • Atrial fibrillation
  • Visual disturbance
  • Hypersensitivity to components
  • Hepatic impairment
  • Acute decompensated heart failure
  • Clinically significant hypotension
  • Sick sinus syndrome (patients without pacemaker)
  • Sino-atrial block (patients without pacemaker)
  • 2nd-3rd degree AV block (patients without pacemaker)
  • clinically significant bradycardia
  • Atrial fibrillation
  • Pacemaker dependence
  • Atazanavir
  • Clarithromycin
  • Cobicistat
  • Conivaptan
  • Darunavir
  • Elvitegravir/cobicistat/emtricitabine/tenofovir
  • Fosamprenavir
  • Idelalisib
  • Imatinib
  • Indinavir
  • Isoniazid
  • Itraconazole
  • Ketoconazole
  • Levoketoconazole
  • Lopinavir
  • Nefazodone
  • Nelfinavir
  • Nicardipine
  • Nirmatrelvir/ritonavir
  • Posaconazole
  • Quinidine
  • Ritonavir
  • Saquinavir
  • Tipranavir
  • Voriconazole

                          Drug Status

Availability Prescription only
Pregnancy Category D
Breastfeeding Contraindicated
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Ivadin 5mg Tablet 10’s Ind-Swift Ltd Ind-Swift Ltd
Ivadin 7.5mg Tablet 10’s Ind-Swift Ltd Ind-Swift Ltd
Procoralan 5mg Tablet 56’s Les Laboratoires Harley’s Ltd
Procoralan 7.5mg Tablet 56’s Les Laboratoires Harley’s Ltd