- Hypertension
- 1 tab OD. May be increased every 1-2 weeks. Max: 300 mg/25 mg/day
Tablet:
- 150mg/12.5mg
- 300mg/12.5mg
- Best taken in the morning due to the diuresis effect of hydrochlorothiazide (peaks in 4 hours)
Irbesartan: Angiotensin II receptor (ARB) blocker
Hydrochlorothiazide: Thiazide diuretic
- URTI
- Dizziness
- Orthostatic hypotension
- Fatigue
- Diarrhoea
- Dyspepsia
- Angioedema
- Musculoskeletal pain
- Renal impairment
- Anxiety
- Hyperglycemia
- Glycosuria
- Hyperuricaemia
- Hyponatremia
- Anorexia
- Impotence
- Gastric irritation
- Hypokalemia
- Fatigue
- Skin reactions
- Hypersensitivity to components or sulphonamides
- Pregnancy; causes oligohydramnios in foetus resulting in foetus injury or death. Withdraw as soon as pregnancy is detected
- Anuria
- Breastfeeding (HCTZ dose >50 mg/day)
- ACEIs
- NSAIDs
- Amikacin
- Lithium
- Erythromycin
- Halofantrine
- Pentamidine
- Terfenadine
- Mannitol
Drug Status
| Availability | Prescription only |
| Pregnancy | Category D |
| Breastfeeding | Contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Andaran HCT | 150mg/12.5mg | Tablet | 28’s | Sandoz GMBH | Novartis Kenya |
| Andaran HCT | 300mg/12.5mg | Tablet | 28’s | Sandoz GMBH | Novartis Kenya |
| Arbi-D | 150mg/12.5mg | Tablet | 10’s | Pharmevo Ltd | Harley’s Ltd |
| Co-Aprovel | 150mg/12.5mg | Tablet | 28’s | Sanofi-Aventis | Ressourcethica Kenya |
| Co-Aprovel | 300mg/12.5mg | Tablet | 28’s | Sanofi-Aventis | Ressourcethica Kenya |
| Corycardon | 150mg/12.5mg | Tablet | 30’s | Delorbis Pharma | Europa Healthcare |
| Corycardon | 300mg/12.5mg | Tablet | 30’s | Delorbis Pharma | Europa Healthcare |
| Irovel H | 150mg/ 12.5mg | Tablet | 30’s | Sun Pharma | Sun Pharma |
| Medisart 300H | 300mg/12.5mg | Tablet | 30’s | Medistar Pharma | Medistar Pharma |
| Medisart H | 150mg/12.5mg | Tablet | 30’s | Medistar Pharma | Medistar Pharma |
| Vivazac Plus | 150mg/12.5mg | Tablet | 30’s | United Pharma | Generics Africa |
| Vivazac Plus | 300mg/25mg | Tablet | 30’s | United Pharma | Generics Africa |