- Essential hypertension
- 25-50mg daily in divided doses
- Heart failure:
- 25mg 2-4 times daily. Can be increased every 2 days if necessary. Maintenance: 50-75mg QID
Slow IV: 5-10mg over 10 minutes. Repeat after 20 minutes if necessary.
Tablet: 25mg
Injection: 20mg/ml
IV Preparation:
- Prepare immediately just before use.
- Try to reduce contact with metal parts during preparation and administration of the drug.
Phthalazine-derivative antihypertensive agent. Vasodilator.
It reduces peripheral resistance and blood pressure due to direct vasodilation of the smooth muscle. Diastolic pressure may be decreased more than the systolic pressure.
- Headache
- Angina pectoris
- Diaarhoea
- Anorexia
- Flushing
- Hypotension
- Joint disorders
- Nausea
- Palpitations
- Tachycardia
- Toxic reactions
- Myalgia
- Acute porphyria
- Cor pulmonale
- Dissecting aortic aneurysm
- High output heart failure
- Idiopathic SLE
- Myocardial insufficiency due to mechanical obstruction
- Severe tachycardia
- Diazoxide
- Thiazide diuretics
- Beta blockers
- Indomethacin
Drug Status
Availability | Prescription only |
Pregnancy | Category C; Contraindicated |
Breastfeeding | Excreted in milk; use with caution |
Schedule | Not controlled |
BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
---|---|---|---|---|---|
Apresoline | 25mg | Tablet | 100’s | Rottendorf Pharma | Surgipharm Ltd |
Apresoline | 20mg/mL | Injection | 5’s | Rottendorf Pharma | Surgipharm Ltd |
Hydralazine | 25mg | Tablet | 100’s | Cosmos Ltd | Cosmos Ltd |
Hydralazine | 25mg | Tablet | 100’s | Laboratory & Allied | Laboratory & Allied |
Hydralazine | 20mg/mL | Injection | 1’s | Asence Pharma | Medisel Kenya |