- Hypertension:
- Initially 5mg OD. Maintenance dose is 20mg. Max 40mg/day
- Heart failure/symptomatic left ventricular dysfunction:
- Initially 2.5mg OD. Maintenance dose is 20mg.
Dosing considerations:
Renal impairment or on diuretic: 2.5mg OD
Tablet:
- 5mg
- 10mg
- 20mg
- It has decreased efficacy as monotherapy in Blacks
ACE inhibitor
It interferes with the angiotensin converting enzyme thereby inhibiting conversion of angiotensin I to angiotensin II which is a potent vasoconstrictor, therefore dilates arteries and veins.
- Persistent dry cough
- Hypotension
- Dizziness
- Fatigue
- Headache
- GI disturbances
- URTIs
- Skin rashes
- Angioedema
- Renal impairment
- Hyperkalemia
- Hyponatremia
- Voice changes
- Hypersensitivity to component/class
- Pregnancy
- History of angioedema with ACEI use
- Renal vascular disease
- Porphyria
- NSAIDs
- Valsartan
- Potassium sparing diuretics or potassium supplements in HF
Drug Status
| Availability | Prescription only |
| Pregnancy | Category D |
| Breastfeeding | Contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Acepril | 5mg | Tablet | 30’s | Laboratory & Allied | Laboratory & Allied |
| Cardace | 10mg | Tablet | 28’s | Cosmos Ltd | Cosmos Ltd |
| Cardace | 20mg | Tablet | 28’s | Cosmos Ltd | Cosmos Ltd |
| Cardace | 5mg | Tablet | 28’s | Cosmos Ltd | Cosmos Ltd |
| Cortec | 10mg | Tablet | 20’s | Nabiqasim Industries | Harley’s Ltd |
| Cortec | 5mg | Tablet | 20’s | Nabiqasim Industries | Harley’s Ltd |
| Dawapril | 10mg | Tablet | 100’s | Dawa Ltd | Dawa Ltd |
| Dawapril | 5mg | Tablet | 100’s | Dawa Ltd | Dawa Ltd |
| Ena-Denk | 10mg | Tablet | 30’s | Denk Pharma | Laborex Kenya |
| Ena-Denk | 20mg | Tablet | 30’s | Denk Pharma | Laborex Kenya |
| Enacare | 10mg | Tablet | 100’s | Careplus Ltd | Careplus Ltd |
| Enacare | 5mg | Tablet | 100’s | Careplus Ltd | Careplus Ltd |
| Enapril | 20mg | Tablet | 100’s | Intas Pharma | Accord Healthcare |
| Enapril | 10mg | Tablet | 100’s | Intas Pharma | Accord Healthcare |
| Enapril | 5mg | Tablet | 100’s | Intas Pharma | Accord Healthcare |
| Enaril | 5mg | Tablet | 100’s | Beximco Pharma | Madawa Pharma |
| Encardil | 5mg | Tablet | 100’s | Medley Pharma | Zawadi Healthcare |
| Encardil | 10mg | Tablet | 100’s | Medley Pharma | Zawadi Healthcare |
| Enitas | 2.5mg | Tablet | 30’s | Biodeal Labs | Biodeal Labs |
| Enitas | 5mg | Tablet | 30’s | Biodeal Labs | Biodeal Labs |
| Enitas | 10mg | Tablet | 30’s | Biodeal Labs | Biodeal Labs |
| Enril | 5mg | Tablet | 30’s | Galaxy Pharma | Galaxy Pharma |
| Enril | 10mg | Tablet | 30’s | Galaxy Pharma | Galaxy Pharma |
| Enril | 20mg | Tablet | 30’s | Galaxy Pharma | Galaxy Pharma |
| Envas | 5mg | Tablet | 100’s | Cadila Pharm | Cadila Pharm |
| Envas | 10mg | Tablet | 100’s | Cadila Pharm | Cadila Pharm |
| Flaminopril | 10mg | Tablet | 100’s | Flamingo | Harley’s Ltd |
| Flaminopril | 5mg | Tablet | 100’s | Flamingo | Harley’s Ltd |
| Korandil | 10mg | Tablet | 100’s | Remedica Ltd | Twokay Chemicals |
| Korandil | 5mg | Tablet | 100’s | Remedica Ltd | Twokay Chemicals |
| Priloten | 5mg | Tablet | 10’s | Medox Pharma | Medox Pharma |
| Priloten | 10mg | Tablet | 10’s | Medox Pharma | Medox Pharma |
| Vasopril | 10mg | Tablet | 100’s | Square Pharma | Ace Pharma |
| Vasopril | 5mg | Tablet | 100’s | Square Pharma | Ace Pharma |
| Zotapril | 10mg | Tablet | 100’s | Zawadi Healthcare | Zawadi Healthcare |
| Zotapril | 5mg | Tablet | 100’s | Zawadi Healthcare | Zawadi Healthcare |