- Hypertension:
- 5-50mg BD/TDS. Increase dose by 12.5-25mg every 1-2 weeks. Max 200mg/day
- Decreased efficacy as a monotherapy in Blacks
- If on diuretics, use lower initial dose
- Heart failure with reduced ejection fraction:
- 25-12mg TDS; initially under medical supervision. Maintenance 25mg BD/TDS
- Acute MI:
- Initially 6.25 mg x1 on day 3 post-MI
- Titrate up as tolerated every 3-7 days
- Diabetic nephropathy:
- 25mg TDS
Tablet:
- 25mg
To be taken 1 hour before meals
ACE inhibitor
It interferes with the angiotensin converting enzyme thereby inhibiting conversion of angiotensin I to angiotensin II which is a potent vasoconstrictor, therefore dilates arteries and veins
- Hypotension
- Dizziness
- Fatigue
- Headache
- GI disturbances
- URTIs
- Skin rashes
- Angioedema
- Renal impairment
- Hyperkalemia
- Hyponatremia
- Voice changes
- Hypersensitivity to class/compound
- Anuria
- History of angioedema
- Bilateral renal artery stenosis
- Pregnancy
- Antacids
- Indomethacin
- Phenothiazines
- Rifampicin
- Allopurinol
- Digoxin
- Lithium
- Tetracycline
- Potassium sparing diuretics
- Potassium preps
- Valsartan
- NSAIDs
Drug Status
| Availability | Prescription only |
| Pregnancy | Category D |
| Breastfeeding | Use with caution |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Angiopril | 25mg | Tablet | 100’s | Medox Pharma | Medox Pharma |
| Captocos | 25mg | Tablet | 30’s | Cosmos Ltd | Cosmos Ltd |
| Captolab | 25mg | Tablet | 100’s | Laboratory & Allied | Laboratory & Allied |
| Captopril Denk | 25mg | Tablet | 100’s | Denk Pharma | Laborex Kenya |
| Cardopril | 25mg | Tablet | 100’s | Beximco Pharma | Madawa Pharma |