- Primary hypercholesterolemia, including familial hypercholesterolemia(heterozygous variant) or combined (mixed) hyperlipidaemia already controlled with the individual 2 substances given concurrently at the same dose level as in the fixed dose combination, but as separate products:
- PO 1 tab OD
Tablet:
- 10mg/10mg
- 20mg/10mg
- Taken without regards to meals
Atorvastatin: Statin. It works primarily via inhibition of HMG-CoA (hydroxymethylglutaryl-coenzyme A) reductase, the rate-limiting enzyme in the cholesterol biosynthesis pathway thereby slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain and other parts of the body.
Ezetimibe: Selective cholesterol-absorption inhibitors. It localizes at the brush border of the small intestine and inhibits the absorption of cholesterol, leading to a decrease in the delivery of intestinal cholesterol to the liver.
- Diarrhoea
- Myalgia
- Common cold symptoms
- Muscle aches
- Upper respiratory tract infection
- Joint pain
- Hypersensitivity to drug or ingredient
- Active liver disease
- Pregnancy
- Breastfeeding
- Cisapride
- Colchicine
- Lonafarnib
- Posaconazole
- Ritonavir
Drug Status
| Availability | Prescription only |
| Pregnancy | Contraindicated |
| Breastfeeding | Contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Atorid EZ | 10mg/10mg | Tablet | 30’s | Zest Pharma | Synermed Pharma |
| Atorid EZ | 20mg/10mg | Tablet | 30’s | Zest Pharma | Synermed Pharma |
| Aztor EZ | 10mg/10mg | Tablet | 10’s | Sun Pharma | Sun Pharma |