Amlodipine/ Olmesartan

Tablet:

• 5mg/20mg
• 5mg/40mg
• 10mg/20mg

• May cause you to feel lightheaded or weak especially when you stand up.  Rise slowly if you have been sitting or lying down.

Amlodipine: Dihydropyridine calcium channel blocker. It inhibits the influx of calcium ions into both vascular smooth muscle and cardiac muscle. The contraction of cardiac muscle and vascular smooth muscle are dependent on the movement of extracellular calcium ions into these cells by specific ion channels.

Olmesartan: Angiotensin II receptor antagonist (ARB). It binds to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a reduction in arterial blood pressure.

• Peripheral edema
• Fatigue
• Palpitations
• Dizziness
• Nausea
• Flushing
• Eczematous eruptions (chronic use in elderly patients)

• Hypersensitivity to drug or ingredient
• Pregnancy

WARNING

• It affects renin-angiotensin system causing oligohydramnios, which may result in fetal injury and/or death. Discontinue as soon as pregnancy is detected

• Aliskiren
• Cisapride
• Isocarboxazid
• Sparsentan
• Dantrolene