Amlodipine/ Hydrochlorothiazide/ Olmesartan

Tablet:

• 5mg/12.5mg/20mg
• 5mg/12.5mg/40mg

• Chest pain may become worse when you first start taking this medicine or when your dose is increased
• May be taken with or without food

Amlodipine: Dihydropyridine calcium channel blocker. It inhibits the influx of calcium ions into both vascular smooth muscle and cardiac muscle. The contraction of cardiac muscle and vascular smooth muscle are dependent on the movement of extracellular calcium ions into these cells by specific ion channels. It is also considered a peripheral arterial vasodilator that exerts its action directly on vascular smooth muscle to lead to a reduction in peripheral vascular resistance, causing a decrease in blood pressure.

Hydrochlorothiazide: Thiazide diuretic. It inhibits sodium reabsorption in distal renal tubules, resulting in increased excretion of water and of sodium, potassium and hydrogen ions.

Olmesartan: Angiotensin II receptor antagonist (ARB). It binds to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a reduction in arterial blood pressure.

• Dizziness
• Peripheral edema
• Headache
• Fatigue
• Nasopharyngitis
• Muscle spasms
• Nausea
• Diarrhea
• UTI
• Joint swelling
• BUN/Cr
• Elevated ALT/ASR
• Hyperuricemia
• Eczematous eruptions (chronic use in elderly patients)

• Hypersensitivity to drug or ingredient
• Hypersensitivity to sulfonamides
• Anuria
• CrCl <10
• Pregnancy
• Breastfeeding (>50 mg/day HCTZ dose)

WARNING

• Fetal/neonatal morbidity/mortality may occur when drugs that act directly on the renin-angiotensin system are used in pregnancy
• Discontinue drug immediately once pregnancy detected

• Aliskiren
• Cisapride
• Dofetilide
• Isocarboxazid
• Sparsentan