Amlodipine/ Hydrochlorothiazide

Tablet:

• 5mg/12.5mg
• 5mg/12.5mg

• Taken without regards to meals
• Best taken in the morning

Amlodipine: Dihydropyridine calcium channel blocker. It inhibits the influx of calcium ions into both vascular smooth muscle and cardiac muscle. The contraction of cardiac muscle and vascular smooth muscle are dependent on the movement of extracellular calcium ions into these cells by specific ion channels.

Hydrochlorothiazide: Thiazide diuretic. It inhibits sodium reabsorption in distal renal tubules, resulting in increased excretion of water and of sodium, potassium and hydrogen ions.

• Glucose intolerance (low or high level of glucose)
• Ankle swelling
• Sleepiness
• Headache
• Flushing
• Tiredness
• Nausea
• Decreased potassium level in the blood
• Increased blood uric acid
• Altered blood lipid level

• Cardiogenic shock
• Heart valve problem (stenosis)
• Hypotension
• Liver disease,
• Kidney disease
• Heart failure
• Hypokalemia
• Anuria

• Lithium
• Digoxin
• Metformin
• Sildenafil
• Simvastatin
• Enalapril
• Lisinopril
• Ramipril
• Cyclosporine