- Malignant hypercalcemia:
- IV 4mg *1
- Consider retreatment after >7 days
- Solid tumor-associated bone metastases:
- IV 4mg every 3-4 weeks
- IV 4mg every 3-4 weeks
- Multiple myeloma:
- IV 4mg every 3-4 weeks
- Osteogenesis imperfect in children (Off-label):
- ≥1 year: IV 0.05mg/kg/dose every 6 months
- Max: 4mg/dose
Injection: 4mg/5mL
- In malignant hypercalcemia use:
- Avoid invasive dental procedure
- Maintain adequate hydration prior to treatment
- Ensure appropriate hydration especially in patients on diuretics
- Infuse >15 minutes
- Infusion of solution must be completed within 24 hours of initial reconstitution
Bisphosphonate
It inhibits osteoclast activity, reducing bone resorption and turnover thereby increasing bone density
- Musculoskeletal pain
- Pain
- Nausea
- Vomiting
- Anemia
- Fatigue
- Fever
- Rigors
- Dyspnea
- Diarrhea
- Arthralgia
- Myalgia
- Cough
- Edema
- Headache
- Dizziness
- Weight loss
- Paresthesia
- Hypokalemia
- Influenza-like symptoms
- Dehydration
- Depression
- Decreased appetite
- Agitation
- UTI
- Hypophosphatemia
- Neutropenia
- Hypoesthesia
- Alopecia
- Candidiasis
- Hypomagnesaemia
- Anxiety
- Dermatitis
- Hypotension
- Thrombocytopenia
- Dyspepsia
- Stomatitis
- Sore throat
- Uri
- Acute phase reaction
- Dysphagia
- Granulocytopenia
- Hypocalcemia
- Pancytopenia
- Somnolence
- Mucositis
- Asthenia
- Increased Cr
- Moniliasis
- Hypersensitivity to components/class
- Pregnancy
- Nononcologic uses: hypocalcemia and severe renal impairment
- Cidofovir
Drug Status
Availability | Prescription only |
Pregnancy | Category D |
Breastfeeding | Contraindicated |
Schedule | Not controlled |
BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
---|---|---|---|---|---|
Amnol | 4mg/5mL | Injection | 1’s | Venus Remedies | Surgipharm Ltd |
Xolinic | 4mg | Injection | 1's | PSM Pharma | PSM Pharma |
Zoldron | 4mg/5mL | Injection | 1’s | Getwell Pharma | Nairobi Enterprises |
Zoledro-Denk | 4mg/5mL | Injection | 1’s | Denk Pharma | Laborex Kenya |
Zoleone | 4mg/5mL | Injection | 1’s | Atlanta Biologicals | Synermed Pharma |
Zolrex | 4mg/5mL | Injection | 1’s | Innorex Pharma | Sai Pharma |
Zometa | 4mg/5mL | Injection | 1’s | Novartis Kenya | Novartis Kenya |